SynthesisChest2019
Use of Balloon Atrial Septostomy in Patients With Advanced Pulmonary Arterial Hypertension: A Systematic Review and Meta-Analysis.
Synthesis in Chest, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 62 citations in OpenAlex.
- First in-human modified atrial septostomy combining radiofrequency ablation and balloon dilation.Heart (British Cardiac Society) · 2022Trial
- Interventional strategies for pulmonary arterial hypertension: Current perspectives and future directions.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Review
- Safety and Efficacy of a Novel Atrial Flow Regulator in Patients With Severe Pulmonary Arterial Hypertension: The AFR-Prophet Study.Journal of the Society for Cardiovascular Angiography & Interventions · 2026Article
- Article
- Case Report: Managing a patent foramen ovale complicated by severe left-sided heart failure and multiple thromboembolic events.Frontiers in cardiovascular medicine · 2026Article
- Pathophysiology and management of right ventricular failure in critically ill patients: A narrative review.World journal of critical care medicine · 2025Review
- Pulmonary Hypertension: Let's Take Stock!Life (Basel, Switzerland) · 2025Review
- Atrial septostomy in the management of pulmonary arterial hypertension: past, present, and future.European journal of medical research · 2025Review
- Case Report: A case of severe pulmonary hypertension combined with FBN1 mutation associated geleophysic dysplasia.Frontiers in pediatrics · 2025Article
- Revisiting Acute Decompensated Right Ventricle Failure in Pulmonary Arterial Hypertension.The open respiratory medicine journal · 2025Review
- Transplantation, bridging, and support technologies in pulmonary hypertension.The European respiratory journal · 2024Review
- Diagnosis and Management of Pulmonary Hypertension: New Insights.Diagnostics (Basel, Switzerland) · 2024Review
- Article
- Recent Advances in the Treatment of Pulmonary Arterial Hypertension Associated with Connective Tissue Diseases.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Lung Transplantation for Pulmonary Arterial Hypertension: Optimized Referral and Listing Based on an Evolving Disease Concept.Journal of cardiovascular development and disease · 2023Review
- Case report: Beneficial long-term effect of the atrial-flow-regulator device in a pediatric patient with idiopathic pulmonary arterial hypertension and recurring syncope.Frontiers in cardiovascular medicine · 2023Article
- Diagnosis and management of pulmonary arterial hypertension.Breathe (Sheffield, England) · 2022Review
- Right Heart Catheterization in Pediatric Pulmonary Arterial Hypertension: Insights and Outcome from a Large Tertiary Center.Journal of clinical medicine · 2022Article
- Mechanical circulatory support devices and treatment strategies for right heart failure.Frontiers in cardiovascular medicine · 2022Review
- Sustained Hemodynamic and Clinical Improvements for a Patient With Idiopathic Pulmonary Arterial Hypertension Over 1.5 Years After Balloon Atrial Septostomy: A Case Report.Frontiers in cardiovascular medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 8 institutions in 2 countries.
Funding
Abstract
backgroundDespite the use and purported benefits of balloon atrial septostomy (BAS), its safety, efficacy, and therapeutic role in the setting of advanced pulmonary arterial hypertension (PAH) are not well defined.
objectiveThe goal of this study was to conduct a systematic review and meta-analysis to better determine the evidence supporting the use of BAS in PAH.
methodsMEDLINE, Scopus, Cochrane Library, and Clinicaltrials.gov were searched from inception through May 2018 for original studies reporting outcomes with PAH prior to and following BAS. Studies comparing BAS vs other septostomy procedures were excluded. Weighted mean differences and 95% CIs were pooled by using a random effects model.
resultsSixteen studies comprising 204 patients (mean age, 35.8 years; 73.1% women) were included. Meta-analysis revealed significant reductions in right atrial pressure (-2.77 mm Hg [95% CI, -3.50, -2.04]; P < .001) and increases in cardiac index (0.62 L/min/m
conclusionsThe present analysis suggests that BAS is relatively safe in advanced PAH, with beneficial hemodynamic effects. The relatively high postprocedural and short-term survival with less impressive long-term survival suggest a bridging role for BAS; its contribution to this change needs to be verified by using a comparator group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.