Evidence map›Paper›PMID 30910476›Full record

ArticleBioorganic & medicinal chemistry2019

Development of a dual-wavelength fluorescent nanoprobe for in vivo and in vitro cell tracking consecutively.

Hong Vu, Jun Zhou, Yihui Huang, Amirhossein Hakamivala, Min Kyung Khang, Liping Tang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Hong VuBioengineering Department, University of Texas at Arlington, Arlington, TX, USA; Progenitec Inc., 7301 West Pioneer Parkway Suite B, Arlington, TX 76013, USA.
Jun ZhouBioengineering Department, University of Texas at Arlington, Arlington, TX, USA.
Yihui HuangBioengineering Department, University of Texas at Arlington, Arlington, TX, USA.
Amirhossein HakamivalaBioengineering Department, University of Texas at Arlington, Arlington, TX, USA.
Min Kyung KhangBioengineering Department, University of Texas at Arlington, Arlington, TX, USA; Chemistry and Biochemistry Department, University of Texas at Arlington, Arlington, TX, USA.
Liping TangBioengineering Department, University of Texas at Arlington, Arlington, TX, USA. Electronic address: ltang@uta.edu.
The University of Texas at Arlington · USProgenitec (United States) · US

Funding

DEVELOPMENT OF RATIOMETRIC IMAGING PROBE SYSTEM FOR MONITORING INFLAMMATIONR44GM101776 · NIGMS · PROGENITEC, INC. · PI HU, WENJING · 2016 to 2017
$1.3M
DEVELOPMENT OF RATIOMETRIC IMAGING PROBE SYSTEM FOR MONITORING INFLAMMATIONR43GM101776 · NIGMS · PROGENITEC, INC. · PI HU, WENJING · 2012 to 2012
$220k
NIGMS NIH HHS R43 GM101776NIGMS NIH HHS R44 GM101776
6 · The paper itself

Abstract

Many imaging probes have been developed for a wide variety of imaging modalities. However, no optical imaging probe could be utilized for both microscopic and whole animal imaging. To fill the gap, the dual-wavelength fluorescent imaging nanoprobe was developed to simultaneously carry both visible-range fluorescent dye and near-infrared (NIR) dye. Emission scan confirms that the nanoprobe exhibits two separate peaks with strong fluorescent intensity in both visible and NIR ranges. Furthermore, the dual-wavelength fluorescent nanoprobe has high photostability and colloidal stability, as well as long shelf-life. In vitro cell culture experiments show that the nanoprobe has the ability to label different types of cells (namely, esophageal, prostate, fibroblast and macrophage cell) for fluorescent microscope imaging. More importantly, cell tracking experiments confirm that cell migration and distribution in various organs can be tracked in real time using in vivo whole-body NIR imaging and in vitro microscopic imaging, respectively.

Indexed as

AnimalsCarbocyaninesCell LineCell SurvivalCell TrackingEsophageal NeoplasmsFluorescein-5-isothiocyanateFluorescent DyesMiceMicroscopy, FluorescenceNanoparticlesTissue DistributionCarbocyaninesFluorescein-5-isothiocyanateFluorescent DyesCell labelingFluorescenceHistologyIn vitro imagingIn vivo cell trackingIn vivo imagingNanoparticleNanoprobe

Identifiers

PMID30910476
PMCPMC6469702
OpenAlexW2923080477

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.