ArticleThe American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry2019
The Roles of Apathy and Depression in Predicting Alzheimer Disease: A Longitudinal Analysis in Older Adults With Mild Cognitive Impairment.
Article in The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06914284 (Apathy-related Neurobehavioral Markers of Cognitive Decline in Old-age Bipolar Disorders), which is not on this map. Cited by 49 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Apathy-related Neurobehavioral Markers of Cognitive Decline in Old-age Bipolar Disorders: Proof-of-concept
Who cites it
49 citing papers in PubMed, 4 syntheses or guidelines pooled it, 91 citations in OpenAlex.
- Depression as a prognostic factor for conversion from mild cognitive impairment to all-cause dementia and Alzheimer's disease: a systematic review and meta-analysis of longitudinal studies.Frontiers in public health · 2026Pooled it
- Cognitive markers of resilience to dementia in mild Neurocognitive Impairment: a meta- analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Pooled it
- The effect of physical exercise on apathy in older adults: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Apathy as a Predictor for Conversion From Mild Cognitive Impairment to Dementia: A Systematic Review and Meta-Analysis of Longitudinal Studies.Journal of geriatric psychiatry and neurology · 2023Pooled it
- Cost consequence analysis of Apathy in Dementia Methylphenidate Trial 2 (ADMET 2).International psychogeriatrics · 2023Trial
- Efficacy of a Web App for Cognitive Training (MeMo) Regarding Cognitive and Behavioral Performance in People With Neurocognitive Disorders: Randomized Controlled Trial.Journal of medical Internet research · 2020Trial
- Associations between apathy and global cognition in a 5-year follow-up of individuals with Alzheimer's disease.Journal of neuropsychology · 2026Article
- Apathy, depression, and dementia risk in older adults: A global collaborative study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Uncovering the Role of Neuropsychiatric Symptoms in Cognitive Impairment Progression.Proceedings. IEEE International Conference on Bioinformatics and Biomedicine · 2025Article
- Psychiatric Risk Factors for Progression From Mild Cognitive Impairment to Alzheimer's Disease: A Systematic Review.The American journal of geriatric psychiatry. Open science, education, and practice · 2025Article
- Functional ability in cognitive complaints: The role of neuropsychiatric and cognitive factors in community-dwelling older adults.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2025Article
- Exploring novel therapeutic strategies: Could psychedelic perspectives offer promising solutions for Alzheimer's disease comorbidities?Dialogues in clinical neuroscience · 2025Review
- Apathy Is Associated with Slower Gait and Subjective Cognitive Complaints in a South Indian Community-Dwelling Cohort.Brain sciences · 2025Article
- Neuropsychiatric symptom phenotypes for early detection of risk in older adults.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Classification of AD and bvFTD using neuropsychological and neuropsychiatric variables: a machine learning study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Psychological Distress in Older Adults Living in Puerto Rico during COVID-19.Journal of cross-cultural gerontology · 2025Article
- Predictive regression models for cognitive impairment, dementia, and Alzheimer's disease using real-world electronic health records.Frontiers in neurology · 2025Article
- A bibliometric analysis of research on dementia comorbid with depression from 2005 to 2024.Frontiers in neuroscience · 2025Article
- How do apathetic and depressive symptoms relate to functional capacity? A cross-sectional survey among community-dwelling middle-aged and older adults in Japan.BMC public health · 2024Article
- Optimizing Older Adult Mental Health in Support of Healthy Ageing: A Pluralistic Framework to Inform Transformative Change across Community and Healthcare Domains.International journal of environmental research and public health · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectiveApathy and depression have each been associated with an increased risk of conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD).These symptoms often co-occur and the contribution of each to risk of AD is not clear.
methodsNational Alzheimer's Coordinating Center participants diagnosed with MCI at baseline and followed until development of AD or loss to follow-up (n = 4,932) were included. The risks of developing AD in MCI patients with neuropsychiatric symptoms (NPS) (apathy only, depression only, or both) were compared to that in those without NPS in a multivariate Cox regression survival analysis adjusting for baseline cognitive impairment, years of smoking, antidepressant use, and AD medication use.
resultsThirty-seven percent (N = 1713) of MCI patients developed AD (median follow-up 23 months). MCI patients with both apathy and depression had the greatest risk (hazard ratio [HR] = 1.37; 95% confidence interval [CI]: 1.17-1.61; p < 0.0001; Wald χ
conclusionMCI patients with apathy alone or both apathy and depression are at a greater risk of developing AD compared to those with no NPS. Interventions targeting apathy and depression may reduce risk of AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.