ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2019
Oxalosis Associated With High-Dose Vitamin C Ingestion in a Peritoneal Dialysis Patient.
Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Assessment and management of vitamin status in children with CKD stages 2-5, on dialysis and post-transplantation: clinical practice points from the Pediatric Renal Nutrition Taskforce.Pediatric nephrology (Berlin, Germany) · 2024Guideline
- Extracorporeal treatment for ethylene glycol poisoning: systematic review and recommendations from the EXTRIP workgroup.Critical care (London, England) · 2023Pooled it
- Oxalate Nephropathy in a Patient With Chronic Pancreatitis and Recent Surgery: A Clinical Conundrum.Kidney medicine · 2026Article
- Water-soluble vitamins and trace elements in children with chronic kidney disease stage 5d.Pediatric nephrology (Berlin, Germany) · 2024Review
- Oxalate in Foods: Extraction Conditions, Analytical Methods, Occurrence, and Health Implications.Foods (Basel, Switzerland) · 2023Review
- Prooxidant effects of high dose ascorbic acid administration on biochemical, haematological and histological changes inThe Pan African medical journal · 2023Article
- Vitamin C supplementation is necessary for patients with coronavirus disease: An ultra-high-performance liquid chromatography-tandem mass spectrometry finding.Journal of pharmaceutical and biomedical analysis · 2021Observational
- Food as medicine: targeting the uraemic phenotype in chronic kidney disease.Nature reviews. Nephrology · 2021Review
- Secondary oxalosis induced by xylitol concurrent with lithium-induced nephrogenic diabetes insipidus: a case report.BMC nephrology · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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Abstract
We report a case of systemic oxalosis involving the eyes and joints due to long-term use of high-dose vitamin C in a patient receiving maintenance peritoneal dialysis (PD). This 76-year-old woman with autosomal dominant polycystic kidney disease underwent living unrelated kidney transplantation 10 years earlier. The transplant failed 6 months before presentation, and she initiated hemodialysis therapy before transitioning to PD therapy 4 months later. During the month before presentation, the patient noted worsening arthralgias and decreased vision. Ophthalmologic examination revealed proliferative retinopathy and calcium oxalate crystals. Plasma oxalate level was markedly elevated at 187 (reference range, <1.7) μmol/L, and urine oxalate-creatinine ratio was high (0.18mg/mg). The patient reported taking up to 4g of vitamin C per day for several years. Workup for causes of primary and secondary hyperoxaluria was otherwise negative. Vitamin C use was discontinued, and the patient transitioned to daily hemodialysis for 2 weeks. Plasma oxalate level before the dialysis session decreased but remained higher (30-53μmol/L) than typical for dialysis patients. Upon discharge, the patient remained on thrice-weekly hemodialysis therapy with stabilized vision and improved joint symptoms. This case highlights the risk of high-dose vitamin C use in patients with advanced chronic kidney disease, especially when maintained on PD therapy.
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