Evidence map›Paper›PMID 30910126›Full record

ReviewVascular pharmacology2019

Lessons learned from a lncRNA odyssey for two genes with vascular functions, DLL4 and TIE1.

Tamjid A Chowdhury, Keguo Li, Ramani Ramchandran

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Vascular pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Tamjid A ChowdhuryDepartment of Obstetrics and Gynecology, and Developmental Vascular Biology Program, Children's Research Institute, Medical College of Wisconsin, USA.
Keguo LiDepartment of Anesthesiology, Children's Research Institute, Medical College of Wisconsin, USA.
Ramani RamchandranDepartment of Pediatrics, Obstetrics and Gynecology, and Developmental Vascular Biology Program, Children's Research Institute, Medical College of Wisconsin, USA. Electronic address: rramchan@mcw.edu.
Children's Hospital of Wisconsin · US

Funding

Delta like-4 long non-coding RNA function in angiogenesis and vascular anomaliesR01HL123338 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI RAMCHANDRAN, RAMANI · 2015 to 2018
$1.8M
NHLBI NIH HHS R01 HL123338
6 · The paper itself

Abstract

Pervasive transcription is a feature of the human genome that requires better understanding. Over the last decade or so, RNA species longer than 200 nucleotides-dubbed long non-coding RNA (lncRNAs)-had been found in sense or anti-sense orientation within or outside of genes that encode proteins. Importantly, lncRNA-mediated gene regulation and the elements that control lncRNA expression are a source of fascination among molecular biologists. In vascular biology, a dozen or so lncRNAs had been identified, and progress occurs each day. In this review, we highlighted our laboratories' contribution to the lncRNA field by discussing lessons learned from two lncRNAs in the tyrosine kinase containing immunoglobulin and epidermal growth factor homology1 (Tie1) and delta-like 4 (Dll4) loci. These genes are responsible for basic vascular patterning and pathophysiological remodeling in angiogenesis.

Indexed as

Adaptor Proteins, Signal TransducingAnimalsBody PatterningCalcium-Binding ProteinsGene Expression RegulationGene Expression Regulation, DevelopmentalHumansIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsModels, AnimalNeovascularization, PhysiologicReceptor, TIE-1RNA, Long NoncodingSignal TransductionVascular RemodelingZebrafishAdaptor Proteins, Signal TransducingCalcium-Binding ProteinsDLL4 protein, humanDll4 protein, zebrafishIntercellular Signaling Peptides and ProteinsIntracellular Signaling Peptides and ProteinsReceptor, TIE-1RNA, Long Noncodingtie1 protein, zebrafishZebrafish ProteinsAngiogenesisCRISPRiDll4Endothelial cellsMorpholinosTie1VascularZebrafish

Identifiers

PMID30910126
PMCPMC6436643
OpenAlexW2922757129

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.