Evidence map›Paper›PMID 30910055›Full record

ArticleChinese journal of natural medicines2019

Houttuynia cordata polysaccharide alleviated intestinal injury and modulated intestinal microbiota in H1N1 virus infected mice.

Mei-Yu Chen, Hong Li, Xiao-Xiao Lu, Li-Jun Ling, Hong-Bo Weng, Wei Sun, Dao-Feng Chen, Yun-Yi Zhang

Open access · greenAbstract read
In one paragraph

Article in Chinese journal of natural medicines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Review
  7. An anti-complement homogeneous polysaccharide fromActa pharmaceutica Sinica. B · 2025
    Article
  8. Article
  9. Review
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  14. Article
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  17. Pharmacological Effects ofPharmaceuticals (Basel, Switzerland) · 2022
    Review
  18. Review
  19. Roles of the gut microbiota in severe SARS-CoV-2 infection.Cytokine & growth factor reviews · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mei-Yu ChenDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China.
Hong LiDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China.
Xiao-Xiao LuDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China.
Li-Jun LingDepartment of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China.
Hong-Bo WengDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China.
Wei SunDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China.
Dao-Feng ChenDepartment of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China. Electronic address: dfchen@shmu.edu.cn.
Yun-Yi ZhangDepartment of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China. Electronic address: zhcheng@shmu.edu.cn.
Fudan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Houttuynia cordata polysaccharide (HCP) is extracted from Houttuynia cordata, a key traditional Chinese medicine. The study was to investigate the effects of HCP on intestinal barrier and microbiota in H1N1 virus infected mice. Mice were infected with H1N1 virus and orally administrated HCP at a dosage of 40 mg(kg

Indexed as

AnimalsCytokinesDrugs, Chinese HerbalGastrointestinal MicrobiomeHouttuyniaHypoxia-Inducible Factor 1, alpha SubunitInflammationInfluenza A Virus, H1N1 SubtypeIntestinal MucosaLungMaleMice, Inbred BALB COrthomyxoviridae InfectionsPlant ExtractsPolysaccharidesToll-Like ReceptorsCytokinesDrugs, Chinese HerbalHif1a protein, ratHypoxia-Inducible Factor 1, alpha SubunitPlant ExtractsPolysaccharidesTjp1 protein, ratToll-Like ReceptorsZonula Occludens-1 ProteinH1N1 influenza virusHouttuynia cordataInflammationIntestinal BarrierMicrobiotaPolysaccharide

Identifiers

PMID30910055
PMCPMC7128561
OpenAlexW2940231152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.