ArticleeLife2019
Microglial SIRPα regulates the emergence of CD11c
Open access · goldAbstract read
In one paragraph
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 63 citations in OpenAlex.
- Temporal patterns of microglial activation in white matter following experimental mild traumatic brain injury: a systematic literature review.Acta neuropathologica communications · 2021Pooled it
- CD11c + microglia: From basic research to clinical application.Neural regeneration research · 2026Article
- TrkB promotes the neuronal secretion of soluble Siglec-2 (CD22) to mitigate microglial activation and alleviate depression-like behaviors in male mice.Molecular psychiatry · 2026Article
- Microglial ITAM & ITIM Signaling in Neurodegenerative Disease and Brain Aging.Journal of molecular biology · 2026Review
- Remodeling of the brain immune microenvironment in Alzheimer's disease: interactions among microglia, astrocytes, complement, and the neurovascular unit.Frontiers in immunology · 2026Review
- Cellular Communication Networks Mediated by Microglia in Ischemic Stroke.CNS neuroscience & therapeutics · 2025Review
- Microglia in Brain Aging and Age-Related Diseases: Friends or Foes?International journal of molecular sciences · 2025Review
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- Dendritic cell maturation in cancer.Nature reviews. Cancer · 2025Review
- Free fatty acid receptor 4 modulates dietary sugar preference via the gut microbiota.Nature microbiology · 2025Article
- From trauma to depression: structural, synaptic, epigenetic, and molecular pathways linking early stress to lifelong vulnerability.Frontiers in psychiatry · 2025Review
- The role of inhibitory immune checkpoint receptors in the pathogenesis of Alzheimer's disease.Journal of molecular medicine (Berlin, Germany) · 2025Review
- Microglia and Astrocytes in Alzheimer's Disease: Significance and Summary of Recent Advances.Aging and disease · 2024Review
- Absence of Aquaporin-4 (AQP4) Prolongs the Presence of a CD11c+ Microglial Population during Postnatal Corpus Callosum Development.International journal of molecular sciences · 2024Article
- CD11c-expressing microglia are transient, driven by interactions with apoptotic cells.bioRxiv : the preprint server for biology · 2024Article
- TRPA1 Covalent Ligand JT010 Modifies T Lymphocyte Activation.Biomolecules · 2024Article
- Spatiotemporal dynamics of the CD11cMolecular brain · 2024Article
- Microglial Ffar4 deficiency promotes cognitive impairment in the context of metabolic syndrome.Science advances · 2024Article
- Noteworthy perspectives on microglia in neuropsychiatric disorders.Journal of neuroinflammation · 2023Review
- NF-κB is a critical mediator of post-mitotic senescence in oligodendrocytes and subsequent white matter loss.Molecular neurodegeneration · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors at 5 institutions in 4 countries.
Miho Sato-HashimotoDepartment of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Gunma, Japan.ORCID 0000-0002-0011-2753
Tomomi NozuDepartment of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Gunma, Japan.
Riho ToribaDepartment of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Gunma, Japan.
Ayano HorikoshiDepartment of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Gunma, Japan.
Miho AkaikeDepartment of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Gunma, Japan.
Kyoko KawamotoDepartment of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Gunma, Japan.
Ayaka HiroseDepartment of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Gunma, Japan.
Yuriko HayashiDepartment of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Gunma, Japan.
Hiromi NagaiDepartment of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Gunma, Japan.
Wakana ShimizuDepartment of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Gunma, Japan.
Ayaka SaikiDepartment of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Gunma, Japan.
Tatsuya IshikawaDivision of Brain Structure and Function, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Ruwaida ElhanblyDivision of Brain Structure and Function, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Takenori KotaniDivision of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.
Yoji MurataDivision of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.ORCID 0000-0002-9576-7030
Yasuyuki SaitoDivision of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.ORCID 0000-0002-9291-1383
Masae NaruseDepartment of Molecular and Cellular Neurobiology, Gunma University Graduate School of Medicine, Gunma, Japan.
Koji ShibasakiDepartment of Molecular and Cellular Neurobiology, Gunma University Graduate School of Medicine, Gunma, Japan.ORCID 0000-0003-2330-1749
Per-Arne OldenborgDepartment of Integrative Medical Biology, Section for Histology and Cell Biology, Umeå University, Umeå, Sweden.
Steffen JungDepartment of Immunology, Weizmann Institute of Science, Rehovot, Israel.ORCID 0000-0003-4290-5716
Takashi MatozakiDivision of Molecular and Cellular Signaling, Department of Biochemistry and Molecular Biology, Kobe University Graduate School of Medicine, Kobe, Japan.ORCID 0000-0002-4393-8416
Yugo FukazawaDivision of Brain Structure and Function, Faculty of Medical Sciences, University of Fukui, Fukui, Japan.
Hiroshi OhnishiDepartment of Laboratory Sciences, Gunma University Graduate School of Health Sciences, Gunma, Japan.ORCID 0000-0002-2534-5449
Gunma University · JPKobe University · JPUniversity of Fukui · JPUmeå University · SEWeizmann Institute of Science · IL
Funding
Japan Society for the Promotion of Science 16K15189Japan Society for the Promotion of Science 25430062Japan Society for the Promotion of Science 26670110Ministry of Education, Culture, Sports, Science, and Technology 24111508Ministry of Education, Culture, Sports, Science, and Technology 26111703
Abstract
A characteristic subset of microglia expressing CD11c appears in response to brain damage. However, the functional role of CD11c
Indexed as
Demyelinating DiseasesAnimalsCD11 AntigensCD47 AntigenMice, KnockoutMicrogliaReceptors, ImmunologicWhite MatterCD11 AntigensCD47 AntigenCd47 protein, mouseItgax protein, mouseReceptors, ImmunologicSirpa protein, mouseCD11cdemyelinationmicrogliamouseneurosciencetissue repairwhite matter
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.