Evidence map›Paper›PMID 30909983›Full record

ArticleBMC research notes2019

No detection of EBV, BKV and JCV in breast cancer tissue samples in Iran.

Razieh Dowran, Negar Joharinia, Akbar Safaei, Sahar Bakhtiyarizadeh, Abootaleb Alidadi Soleimani, Rasool Alizadeh, Sara Mir-Shiri, Jamal Sarvari

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC research notes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Prevalence of BK and JC Polyomaviruses among Patients with Breast Cancer.Asian Pacific journal of cancer prevention : APJCP · 2024
    Article
  7. Review
  8. Epstein-Barr Viral Infection and the Risk for Breast Cancer: A Systematic Review.International journal of hematology-oncology and stem cell research · 2023
    Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Interrelated Oncogenic Viruses and Breast Cancer.Frontiers in molecular biosciences · 2022
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Prevalence of Epstein-Barr virus (EBV) in Iranian Breast Carcinoma Patients.Asian Pacific journal of cancer prevention : APJCP · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Razieh DowranDepartment of Bacteriology & Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Negar JohariniaDepartment of Bacteriology & Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Akbar SafaeiDepartment of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Sahar BakhtiyarizadehDepartment of Bacteriology & Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Abootaleb Alidadi SoleimaniDepartment of Bacteriology & Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Rasool AlizadehDepartment of Bacteriology & Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Sara Mir-ShiriDepartment of Bacteriology & Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Jamal SarvariDepartment of Bacteriology & Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. sarvarij@sums.ac.ir.
Shiraz University of Medical Sciences · IR

Funding

Shiraz University of Medical Sciences 94-9817Shiraz University of Medical Sciences 96-16352Shiraz University of Medical Sciences grant no: 94-9816
6 · The paper itself

Abstract

objectiveThe most common cancer amongst women is breast cancer. Reports on the role of EBV, BKV, and JCV in the development of breast cancer are controversial. Hence, the aim of this study was to determine the frequency of EBV, BKV, and JCV in malignant breast tumors in comparison with benign ones.

resultsA total of 300 breast biopsy tissues were included, of which 150 were malignant and 150 benign. After deparaffinization, tissues were subjected to DNA extraction. β-globin gene was amplified by PCR to evaluate the quality of extracted DNA. In house PCRs assay was performed to detect EBV, JCV, and BKV genome fragment. The mean age of malignant and benign groups was 45.0 ± 9.4 and 35.2 ± 12.1 years old. Out of 150 malignant samples, 146 were ductal, two lobular and two samples both invasive ductal and lobular carcinoma. In the benign group, 96, 52 and two samples were fibroadenoma, fibrocystic, and adenosis types, respectively. Genomic DNA fragment of EBV, BKV, and JCV was not found in any of the malignant and benign breast tissues.

conclusionAccording to our finding, there is the possibility that EBV, BKV, and JCV are not involved in breast cancer pathogenesis.

Indexed as

AdultBK VirusBreast NeoplasmsDNA, ViralFemaleHerpesvirus 4, HumanHumansIranJC VirusMiddle AgedDNA, ViralBKVBreast cancerEBVJCV

Identifiers

PMID30909983
PMCPMC6434965
OpenAlexW2942097266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.