ArticleJournal of translational medicine2019
Development and validation of a prognostic nomogram in gastric cancer with hepatitis B virus infection.
Article in Journal of translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Chronic Hepatitis Virus Infection Are Associated With High Risk of Gastric Cancer: A Systematic Review and Cumulative Analysis.Frontiers in oncology · 2021Pooled it
- The Gut Microbiome in Enteric Viral Infections: Underlying Mechanisms and Therapeutic Approaches.Microorganisms · 2025Review
- Constructing and identifying an eighteen-gene tumor microenvironment prognostic model for non-small cell lung cancer.World journal of surgical oncology · 2024Article
- Gastrointestinal tract and viral pathogens.World journal of virology · 2023Review
- A novel nomogram based on clinical blood indicators for prognosis prediction in curatively resected esophagogastric junction adenocarcinoma patients.Journal of Cancer · 2023Article
- Model established based on blood markers predicts overall survival in patients after radical resection of types II and III adenocarcinoma of the esophagogastric junction.World journal of gastrointestinal surgery · 2022Article
- Construction of a novel signature and prediction of the immune landscape in gastric cancer based on necroptosis-related genes.Scientific reports · 2022Article
- A model established using marital status and other factors from the Surveillance, Epidemiology, and End Results database for early stage gastric cancer.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2022Article
- Review
- Comprehensive Characterization of Transforming Growth Factor Beta Receptor 1 in Stomach Adenocarcinoma Identifies a Prognostic Signature for Predicting Clinical Outcomes and Immune Infiltrates.International journal of general medicine · 2022Article
- Development and validation of a prognostic nomogram for 2018 FIGO stages IB1, IB2, and IIA1 cervical cancer: a large multicenter study.Annals of translational medicine · 2022Article
- Development and external validation of a prognostic nomogram for patients with gastric cancer after radical gastrectomy.Annals of translational medicine · 2021Article
- Identification and validation of a novel ferroptosis-related gene model for predicting the prognosis of gastric cancer patients.PloS one · 2021Article
- PRMT1 is a novel molecular therapeutic target for clear cell renal cell carcinoma.Theranostics · 2021Article
- Development and Validation of a Prognostic Nomogram for Gastric Signet Ring Cell Carcinoma: A Multicenter Population-Based Study.Frontiers in oncology · 2021Article
- Calculating the overall survival probability in patients with cervical cancer: a nomogram and decision curve analysis-based study.BMC cancer · 2020Article
- Development and validation of a novel nomogram to predict overall survival in gastric cancer with lymph node metastasis.International journal of biological sciences · 2020Article
- Cannabidiol Induces Cell Cycle Arrest and Cell Apoptosis in Human Gastric Cancer SGC-7901 Cells.Biomolecules · 2019Article
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6 authors.
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Abstract
backgroundPatients with HBsAg-positive gastric cancer (GC) are a heterogeneous group, and it is not possible to accurately predict the overall survival (OS) in these patients.
methodsWe developed and validated a nomogram to help improve prediction of OS in patients with HBsAg-positive GC. The nomogram was established by a development cohort (n = 245), and the validation cohort included 84 patients. Factors in the nomogram were identified by univariate and multivariate Cox hazard analysis. We tested the accuracy of the nomograms by discrimination and calibration, and plotted decision curves to assess the benefits of nomogram-assisted decisions in a clinical context. Then we evaluated the risk in the two cohort.
resultsSignificant predictors were age, tumor stage, distant metastases, gamma-glutamyl transpeptidase (GGT) and alkaline phosphatase (ALP). The proportional-hazards model (nomogram) was based on pre-treatment characteristics. The nomogram had a concordance index (C-index) of 0.812 (95% CI 0.762-0.862), which was superior than the C-index of AJCC TNM Stage (0.755, 95% CI 0.702-0.808). The calibration plot in the validation cohort based on 5 predictors suggested good agreement between actual and nomogram-predicted OS probabilities. The decision curve showed that the nomogram in predicting OS is better than that of TNM staging system in all range. Moreover, patients were divided into three distinct risk groups for OS by the nomogram: low risk group, middle risk group and high risk group, respectively.
conclusionThis nomogram, using five pre-treatment characteristics, improves prediction of OS in patients with HBsAg-positive gastric cancer. It represents an improvement in prognostication over the current TNM stage. To generalize the use of this nomogram in other groups, additional validation with data from other institutions is required.
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