Evidence map›Paper›PMID 30909915›Full record

Observational studyMalaria journal2019

Does reduced oxygen delivery cause lactic acidosis in falciparum malaria? An observational study.

Hugh W Kingston, Aniruddha Ghose, Voravut Rungpradubvong, M Trent Herdman, Katherine Plewes, Haruhiko Ishioka, Stije J Leopold, Richard J Maude, Benjamas Intharabut, Sanjib Mohanty and 5 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Malaria journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 2 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 5 countries.

Hugh W KingstonMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand. hwfkingston@gmail.com.ORCID http://orcid.org/0000-0003-1869-8307
Aniruddha GhoseChittagong Medical College, Chittagong, Bangladesh.
Voravut RungpradubvongDivision of Cardiology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
M Trent HerdmanMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.
Katherine PlewesMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.
Haruhiko IshiokaMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.
Stije J LeopoldMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.
Richard J MaudeMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.
Benjamas IntharabutMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.
Sanjib MohantyIspat General Hospital, Rourkela, Orissa, India.
Nicholas P J DayMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.
Nicholas J WhiteMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.
Md Amir HossainChittagong Medical College, Chittagong, Bangladesh.
Nicholas M AnsteyGlobal and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, NT, 0909, Australia.
Arjen M DondorpMahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.
Mahidol University · THChittagong Medical College · BDCharles Darwin University · AUChulalongkorn University · THIspat General Hospital · IN

Funding

National Health and Medical Research Council 605807Wellcome Trust
6 · The paper itself

Abstract

backgroundLactic acidosis with an elevated lactate-pyruvate ratio suggesting anoxia is a common feature of severe falciparum malaria. High lactate levels are associated with parasitized erythrocyte sequestration in the microcirculation. To assess if there is an additional contribution to hyperlactataemia from relatively inadequate total oxygen delivery, oxygen consumption and delivery were investigated in patients with malaria.

methodsAdult Bangladeshi and Indian patients with uncomplicated (N = 50) or severe (N = 46) falciparum malaria or suspected bacterial sepsis (N = 27) and healthy participants as controls (N = 26) were recruited at Chittagong Medical College Hospital, Chittagong, Bangladesh and Ispat General Hospital, Rourkela, India. Oxygen delivery (DO

resultsVO

conclusionsReduced total oxygen delivery is not a major contributor to lactic acidosis in severe falciparum malaria.

Indexed as

Acidosis, LacticAdultBangladeshFemaleHumansIndiaMalaria, FalciparumMaleMiddle AgedOxygen ConsumptionSepsisYoung AdultAcidosis, lacticCardiac outputHaemodynamicsMalariaMicrocirculationOxygen consumption

Identifiers

PMID30909915
PMCPMC6434797
OpenAlexW2942291866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.