ArticleBMC infectious diseases2019
Indicators of severe prognosis of scrub typhus: prognostic factors of scrub typhus severity.
Article in BMC infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Article
- Differentiating scrub typhus meningitis from brucellar meningitis in children: A single-center retrospective study.PLoS neglected tropical diseases · 2026Article
- Article
- miR-874-3p Alleviates Macrophage-Mediated Inflammatory Injury in Intracerebral Hemorrhage by Targeting HIPK2.Cell biochemistry and biophysics · 2025Article
- Scrub Typhus Combined With Septic Shock Disseminated Intravascular Coagulation and Significant Hyperfibrinolysis: A Case Report and Review of the Literature.Case reports in infectious diseases · 2025Article
- Retrospective analysis of spatiotemporal variation of scrub typhus in Yunnan Province, 2006-2022.PLoS neglected tropical diseases · 2024Article
- Circulating microRNAs as markers for scrub typhus-associated acute kidney injury.Kidney research and clinical practice · 2024Article
- Three cases of scrub typhus with hemorrhage: a case report and literature review.The Journal of international medical research · 2023Review
- A time-course comparative clinical and immune response evaluation study between the human pathogenic Orientia tsutsugamushi strains: Karp and Gilliam in a rhesus macaque (Macaca mulatta) model.PLoS neglected tropical diseases · 2022Article
- The epidemiology, diagnosis and management of scrub typhus disease in China.Human vaccines & immunotherapeutics · 2021Article
- Anticipating the future: prognostic tools as a complementary strategy to improve care for patients with febrile illnesses in resource-limited settings.BMJ global health · 2021Article
- Orientia tsutsugamushi selectively stimulates the C-type lectin receptor Mincle and type 1-skewed proinflammatory immune responses.PLoS pathogens · 2021Article
- Orientia tsutsugamushi modulates cellular levels of NF-κB inhibitor p105.PLoS neglected tropical diseases · 2021Article
- Serum C-reactive protein and procalcitonin values in acute Q fever, scrub typhus, and murine typhus.BMC infectious diseases · 2020Article
- The Utility of Platelet Indices in Predicting Multiorgan Dysfunction in Scrub Typhus.Interdisciplinary perspectives on infectious diseases · 2020Article
- Clinical and Laboratory Predictors associated with Complicated Scrub Typhus.Infection & chemotherapy · 2019Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundScrub typhus is an acute disease, characterized by symptoms of fever, which occurs due to infection by Orientia tsutsugamushi. In most cases, patients recover from the disease with appropriate treatment, but serious and fatal complications may occur. The present study examined laboratory findings and tumor necrosis factor-alpha (TNF-α) levels of scrub typhus patients to identify the prognostic predictors of disease severity.
methodPatients whose scrub typhus diagnosis was confirmed by elevated indirect fluorescent antibody (IFA) levels and positive polymerase chain reaction (PCR) results were classified according to disease severity into one of three groups; i.e., deceased (n = 7), severe (n = 15), and mild (n = 15) retrospectively registered. Additionally, the usefulness of modified Acute Physiology and Chronic Health Evaluation II (APACHE II) score, C-reactive protein (CRP) level, white blood cell (WBC) count, and TNF-α level as prognostic predictors were examined.
resultThe mean TNF-α levels of the deceased, severe, and mild groups were 53.5 (range: 7.8-147.8), 26.0 (1.7-64.4), and 8.8 pg/mL (4.6-16.0), respectively. The results of Kruskal-Wallis tests showed statistically significant differences between the deceased and severe groups versus the mild group (p = 0.005). CRP level and Modified APACHE II score also differed significantly among the groups (p = 0.046 and 0.007, respectively); however, WBC count did not (p = 0.196).
conclusionAn elevated serum TNF-α level in patients with scrub typhus could predict a severe condition or death and may be useful in predicting patient prognosis.
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