Evidence map›Paper›PMID 30909860›Full record

ArticleBMC developmental biology2019

Differential roles of insulin like growth factor 1 receptor and insulin receptor during embryonic heart development.

Kai Wang, Hua Shen, Peiheng Gan, Susana Cavallero, S Ram Kumar, Ching-Ling Lien, Henry M Sucov

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC developmental biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
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  5. Epicardium-myocardium crosstalk orchestrates heart development.Frontiers in cell and developmental biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Kai WangDepartment of Cardiovascular Surgery, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120, China.
Hua ShenDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. huashen@usc.edu.
Peiheng GanDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Susana CavalleroDepartment of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
S Ram KumarDepartment of Surgery, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Ching-Ling LienSaban Research Institute, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Henry M SucovDepartment of Regenerative Medicine and Cell Biology, Medical University of South Carolina, Charleston, SC, USA. sucov@musc.edu.
University of Southern California · USChildren's Hospital of Los Angeles · USGuangzhou Medical University · CNMedical University of South Carolina · US

Funding

Cardiomyocyte Proliferation &Ventricular MorphogenesisR01HL070123 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI SUCOV, HENRY M · 2002 to 2019
$6.1M
Cxc12 chemokine signaling regulates synchronous development of coronary vessels and myocardiumR01HL130172 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI LIEN, CHING-LING E · 2017 to 2020
$1.7M
NHLBI NIH HHS R01 HL070123NHLBI NIH HHS R01 HL130172
6 · The paper itself

Abstract

backgroundThe embryonic day E10-13 period of mouse heart development is characterized by robust cardiomyocyte proliferation that creates the compact zone of thickened ventricular wall myocardium. This process is initiated by the formation of the epicardium on the outer heart surface, which releases insulin-like growth factor 2 (IGF2) as the primary cardiomyocyte mitogen. Two receptors mediate IGF2 signaling, the IGF1R and the insulin receptor (INSR).

resultsIn this study, we addressed the relative roles of the two IGF2 receptors in mouse heart development. We find that both receptors are expressed in the mouse heart during the E10-13 period, although IGF1R is much more prominently activated by IGF2 than INSR. Genetic manipulation indicates that only Igf1r is required for embryonic ventricular wall morphogenesis. INSR is not hyperactivated in the absence of IGF1R, and INSR does not compensate functionally for IGF1R in the absence of the latter.

conclusionsThese results define the molecular components that are responsible for a major burst of cardiomyocyte proliferation during heart development. These results may also be relevant to understanding the efficiency of regeneration of the mammalian heart after neonatal and adult injury.

Indexed as

AnimalsCell ProliferationHeartInsulin-Like Growth Factor IIMiceMice, KnockoutMyocytes, CardiacOrganogenesisPericardiumReceptor, IGF Type 1Receptor, InsulinIgf1r protein, mouseIGF2 protein, mouseInsulin-Like Growth Factor IIReceptor, IGF Type 1Receptor, InsulinCardiomyocyte proliferationEpicardiumHeart developmentIGF1RIGF2Insulin receptor

Identifiers

PMID30909860
PMCPMC6434851
OpenAlexW2942248619

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.