ReviewStroke2019
Familial Cerebral Cavernous Malformations.
Registry-linked trialAbstract readReview
In one paragraph
Review in Stroke, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01764529 (Modifiers of Disease Severity and Progression in Cerebral Cavernous Malformations), which is not on this map. Cited by 80 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
80citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Modifiers of Disease Severity and Progression in Cerebral Cavernous Malformations
Who cites it
80 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Reporting practices of baseline and surgical variables in spinal cavernous malformation surgery: a systematic review.Neurosurgical review · 2026Pooled it
- Pediatric Intracerebral Hemorrhage Management-Consensus Statement of the International Pediatric Stroke Organization-Part 1: Acute Phase and Workup.Journal of the American Heart Association · 2026Guideline
- Clinical pharmacology and tolerability of REC-994, a redox-cycling nitroxide compound, in randomized phase 1 dose-finding studies.Pharmacology research & perspectives · 2024Trial
- Effect of Simvastatin on Permeability in Cerebral Cavernous Malformation Type 1 Patients: Results from a Pilot Small Randomized Controlled Clinical Trial.Translational stroke research · 2020Trial
- Headache in Cerebral Cavernous Malformations: Clinical, Genetic, and Neuroimaging Associations.Journal of clinical medicine · 2026Article
- Intraventricular giant cavernous malformation mimicking central neurocytoma characterized by digital subtraction angiography: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Review
- Navigating the Eloquent Brain: A Multicenter Study on the Safety and Efficacy of Symptomatic Cavernoma Resection.Brain sciences · 2026Article
- Risk of Clinical Events in Presymptomatic Familial Cerebral Cavernous Malformations.European journal of neurology · 2026Article
- Obstructive hydrocephalus secondary to an anterior mesencephalic cavernous malformation with familial cerebral cavernous malformation syndrome: A case report.Radiology case reports · 2026Article
- Low-flow vascular malformations without arteriovenous shunting of the central nervous system: a pictorial review.Insights into imaging · 2026Article
- The Role of Immune Infiltration and Oxidative Stress in the Progression of Cerebral Cavernous Malformation.Brain and behavior · 2026Review
- Transient Dysphagia as a Presenting Symptom of Familial Cerebral Cavernous Malformation.Cureus · 2026Article
- Familial Cerebral Cavernous Malformations: Pathophysiology, Genetics, Biomarkers, and Treatment Perspectives.Journal of neurochemistry · 2026Review
- Aeromedical decision-making for asymptomatic cerebral cavernous malformations in military pilots.Frontiers in public health · 2026Article
- Clinical Significance of Somatic PIK3CA and MAP3K3 Mutations in Cerebral and Spinal Cavernous Malformations.Translational stroke research · 2025Article
- Familial Cerebral Cavernous Malformations : A Clinical Series and Literature Review.Journal of Korean Neurosurgical Society · 2025Article
- Association of Quality of Life Domains and Clinical Symptoms in Patients With Familial Cerebral Cavernous Malformation.Journal of the American Heart Association · 2025Article
- Late-onset familial cerebral cavernous malformation without a family history: a case description.Quantitative imaging in medicine and surgery · 2025Article
- Common and distinct circulating microRNAs in four neurovascular disorders.Biochemistry and biophysics reports · 2025Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Atif ZafarFrom the Departments of Neurology (A.Z., M.F., A.I., M.R., L.M.), University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque.
Syed A QuadriDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (S.A.Q.).
Mudassir FarooquiFrom the Departments of Neurology (A.Z., M.F., A.I., M.R., L.M.), University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque.
Asad IkramFrom the Departments of Neurology (A.Z., M.F., A.I., M.R., L.M.), University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque.
Myranda RobinsonFrom the Departments of Neurology (A.Z., M.F., A.I., M.R., L.M.), University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque.
Blaine L HartRadiology (B.L.H., M.C.M.), University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque.
Marc C MabrayRadiology (B.L.H., M.C.M.), University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque.
Catherine VigilHarvard University, Cambridge, MA (C.V.).
Alan T TangDepartment of Medicine and Cardiovascular Institute, University of Pennsylvania, Perelman School of Medicine, Philadelphia (A.T.T., M.L.K.).
Mark L KahnDepartment of Medicine and Cardiovascular Institute, University of Pennsylvania, Perelman School of Medicine, Philadelphia (A.T.T., M.L.K.).
Howard YonasNeurosurgery (H.Y.), University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque.
Michael T LawtonDepartment of Neurosurgery, Barrow Neurological Institute, Phoenix, AZ (M.T.L.).
Helen KimDepartment of Anesthesia and Perioperative Care and Department of Epidemiology and Biostatistics, University of California San Francisco (H.K.).
Leslie MorrisonFrom the Departments of Neurology (A.Z., M.F., A.I., M.R., L.M.), University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque.
Funding
VCRC Administration UnitU54NS065705 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KIM, HELEN · 2009 to 2023
$20.8MHEMATOLOGY CLINICAL RESEARCH TRAINING PROGRAMT32HL007439 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI LAWRENCE F BRASS, PETER S KLEIN · 1985 to 2026
$17.1MSomatic mutation(s) and cellular changes in CCM pathogenesisP01NS092521 · NINDS · DUKE UNIVERSITY · PI MARCHUK, DOUGLAS A. · 2015 to 2024
$12.9MTrial Readiness in Cavernous Angiomas with Symptomatic HemorrhageU01NS104157 · NINDS · UNIVERSITY OF CHICAGO · PI AWAD, ISSAM A · 2018 to 2022
$3.8MHeg-CCM Signaling in Cardiovascular Development and DiseaseR01HL094326 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAHN, MARK L · 2009 to 2018
$3.5MTLR4 and the microbiome in CCM diseaseR01NS100949 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI KAHN, MARK L · 2017 to 2021
$2.8MThe molecular pathogenesis of cerebral cavernous malformationsF30NS100252 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI TANG, ALAN TIEN · 2017 to 2018
$80kNHLBI NIH HHS R01 HL094326NHLBI NIH HHS T32 HL007439NINDS NIH HHS F30 NS100252NINDS NIH HHS P01 NS092521NINDS NIH HHS R01 NS100949NINDS NIH HHS U01 NS104157NINDS NIH HHS U54 NS065705
Abstract
PubMed holds no abstract for this paper.
Indexed as
Clinical Trials as TopicHemangioma, Cavernous, Central Nervous SystemHumansMagnetic Resonance Imagingbraindevelopmental venous anomaliesfamilial cerebral cavernous malformationhemosiderinmutation
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT01764529ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.