Evidence map›Paper›PMID 30909654›Full record

ArticleInternational journal of molecular sciences2019

Preliminary Study on Clusterin Protein (sCLU) Expression in PC-12 Cells Overexpressing Wild-Type and Mutated (Swedish)

Beata Pająk, Elżbieta Kania, Anita Gołaszewska, Arkadiusz Orzechowski

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Beata PająkIndependent Laboratory of Genetics and Molecular Biology, Kaczkowski Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, Poland. bepaj@wp.pl.ORCID 0000-0002-3565-8860
Elżbieta KaniaTumor Cell Death Laboratory, Cancer Research UK, Beatson Institute, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK. elakania@gmail.com.
Anita GołaszewskaDepartment of Neuroendocrinology, Centre of Postgraduate Medical Education, Marymoncka 99/103, 01-813 Warsaw, Poland. an_ita@wp.pl.
Arkadiusz OrzechowskiDepartment of Physiological Sciences, Faculty of Veterinary Medicine, Warsaw University of Life Sciences ⁻ SGGW, Nowoursynowska 159, 02-776 Warsaw, Poland. orzechowski_arkadiusz@wp.pl.ORCID 0000-0003-1307-2823
Warsaw University of Life Sciences · PLCancer Research UK · GBWojskowy Instytut Higieny i Epidemiologii · PL

Funding

Ministerstwo Nauki i Szkolnictwa Wyzszego 05-1/KNOW2/2015Narodowym Centrum Nauki UMO-2011/03/B/NZ7/0238Scientific Consortium KNOW "Healthy Animal - Safe Food" Ministry of Science and Higher Education in Poland
6 · The paper itself

Abstract

In this study we attempted to verify the hypothesis that the mevalonate pathway affects amyloid beta precursor protein (AβPP) processing and regulates clusterin protein levels.

Indexed as

MutationAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnimalsCell SurvivalCholesterolClusterinGene Expression RegulationHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMetabolic Networks and PathwaysMevalonic AcidPC12 CellsRatsTerpenesAmyloid beta-PeptidesAmyloid beta-Protein PrecursorCholesterolClusterinHydroxymethylglutaryl-CoA Reductase InhibitorsMevalonic AcidTerpenesAlzheimer’s diseasecholesterolclusterinisoprenoidsmevalonate pathwayrat neuronal pheochromocytoma PC-12 cellsstatins

Identifiers

PMID30909654
PMCPMC6470582
OpenAlexW2923366854

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.