Evidence map›Paper›PMID 30909652›Full record

ArticleCancers2019

Engagement with tNOX (ENOX2) to Inhibit SIRT1 and Activate p53-Dependent and -Independent Apoptotic Pathways by Novel 4,11-Diaminoanthra[2,3-

Chia-Yang Lin, Atikul Islam, Claire J Su, Alexander S Tikhomirov, Andrey E Shchekotikhin, Show-Mei Chuang, Pin Ju Chueh, Yao Li Chen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Chia-Yang LinInstitute of Biomedical Sciences, National Chung Hsing University, Taichung 40227, Taiwan. lcy4534@gmail.com.
Atikul IslamInstitute of Biomedical Sciences, National Chung Hsing University, Taichung 40227, Taiwan. islammiu555@gmail.com.
Claire J SuInstitute of Biomedical Sciences, National Chung Hsing University, Taichung 40227, Taiwan. suc1@mca.org.tw.
Alexander S TikhomirovGause Institute of New Antibiotics, 11B. Pirogovskaya Street, Moscow 119021, Russia. tikhomirov.chem@gmail.com.
Andrey E ShchekotikhinGause Institute of New Antibiotics, 11B. Pirogovskaya Street, Moscow 119021, Russia. shchekotikhin@mail.ru.
Show-Mei ChuangInstitute of Biomedical Sciences, National Chung Hsing University, Taichung 40227, Taiwan. smchuang@dragon.nchu.edu.tw.
Pin Ju ChuehInstitute of Biomedical Sciences, National Chung Hsing University, Taichung 40227, Taiwan. pjchueh@dragon.nchu.edu.tw.
Yao Li Chentian Hospital, Changhua 50008, Taiwan. 31560@cch.org.tw.
National Chung Hsing University · TWD. Mendeleyev University of Chemical Technology of Russia · RUKaohsiung Medical University · TW

Funding

The Grants Council of the President of the Russian Federation for state support of young Russian scientists МК-2474.2018.3The Ministry of Sciences and Technology, Taiwan MOST 106-2320-B-005-008-MY3The Ministry of Sciences and Technology, Taiwan MOST 108-2923-B-005-001-MY3
6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is the most frequent primary malignancy of the liver and is among the top three causes of cancer-associated death worldwide. However, the clinical use of chemotherapy for HCC has been limited by various challenges, emphasizing the urgent need for novel agents with improved anticancer properties. We recently synthesized and characterized a series of 4,11-diaminoanthra[2,3-

Indexed as

anthraquinone derivativesapoptosisc-Mychepatocellular carcinomap53protein acetylationsirtuin 1 (SIRT1)tumor-associated NADH oxidase (tNOX or ENOX2)

Identifiers

PMID30909652
PMCPMC6468551
OpenAlexW2923862432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.