Evidence map›Paper›PMID 30909641›Full record

ArticleViruses2019

Functional RNA Structures in the 3'UTR of Tick-Borne, Insect-Specific and No-Known-Vector Flaviviruses.

Roman Ochsenreiter, Ivo L Hofacker, Michael T Wolfinger

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
10.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 60 citations in OpenAlex.

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  7. West Nile virus unmasked: from gene variability to future challenges.Frontiers in cellular and infection microbiology · 2025
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  11. Xinyang flavivirus, fromThe Journal of general virology · 2024
    Article
  12. Review
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  16. Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM) · 2023
    Review
  17. Recent advances in RNA structurome.Science China. Life sciences · 2022
    Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Roman OchsenreiterDepartment of Theoretical Chemistry, University of Vienna, Währingerstraße 17, 1090 Vienna, Austria. romanoch@tbi.univie.ac.at.ORCID 0000-0003-1126-0513
Ivo L HofackerDepartment of Theoretical Chemistry, University of Vienna, Währingerstraße 17, 1090 Vienna, Austria. ivo@tbi.univie.ac.at.ORCID 0000-0001-7132-0800
Michael T WolfingerDepartment of Theoretical Chemistry, University of Vienna, Währingerstraße 17, 1090 Vienna, Austria. michael.wolfinger@univie.ac.at.ORCID 0000-0003-0925-5205
University of Vienna · AT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Untranslated regions (UTRs) of flaviviruses contain a large number of RNA structural elements involved in mediating the viral life cycle, including cyclisation, replication, and encapsidation. Here we report on a comparative genomics approach to characterize evolutionarily conserved RNAs in the 3 ' UTR of tick-borne, insect-specific and no-known-vector flaviviruses in silico. Our data support the wide distribution of previously experimentally characterized exoribonuclease resistant RNAs (xrRNAs) within tick-borne and no-known-vector flaviviruses and provide evidence for the existence of a cascade of duplicated RNA structures within insect-specific flaviviruses. On a broader scale, our findings indicate that viral 3 ' UTRs represent a flexible scaffold for evolution to come up with novel xrRNAs.

Indexed as

3' Untranslated RegionsGenomicsAnimalsEvolution, MolecularFlavivirusInsectaNucleic Acid ConformationRNA, UntranslatedRNA, Viral3' Untranslated RegionsRNA, UntranslatedRNA, Viralflavivirusnon-coding RNAsecondary structure

Identifiers

PMID30909641
PMCPMC6466055
OpenAlexW2920743503

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.