SynthesisNutrients2019
Coffee Consumption and Risk of Colorectal Cancer: A Systematic Review and Meta-Analysis of Prospective Studies.
Synthesis in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Does drinking coffee reduce the risk of colorectal cancer? A qualitative umbrella review of systematic reviews.Techniques in coloproctology · 2023Pooled it
- Coffee Consumption and Colon Cancer Risk: A Meta- Epidemiological Study of Asian Cohort Studies.Asian Pacific journal of cancer prevention : APJCP · 2020Pooled it
- Dose-response meta-analysis of coffee consumption and risk of colorectal adenoma.European journal of clinical nutrition · 2020Pooled it
- Caffeic acid suppresses cyclin D1 expression by directly binding to ribosomal protein S5 in colorectal cancer cells.Scientific reports · 2026Article
- Large-scale integration of omics and electronic health records to identify potential risk protein biomarkers and therapeutic drugs for cancer prevention.American journal of human genetics · 2026Article
- Decaffeinated coffee consumption and risk of total and site-specific cancer.Annals of oncology : official journal of the European Society for Medical Oncology · 2025Article
- Genome-wide association studies of coffee intake in UK/US participants of European ancestry uncover cohort-specific genetic associations.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- The effect of metabolism-related lifestyle and clinical risk factors on digestive system cancers in East Asian populations: a two-sample Mendelian randomization analysis.Scientific reports · 2024Article
- Review
- The relationship between caffeine consumption and colon cancer prevalence in a nationally representative population.Frontiers in nutrition · 2024Article
- Does caffeine have a double-edged sword role in inflammation and carcinogenesis in the colon?Intestinal research · 2023Review
- Plant-based dietary patterns and the risk of digestive system cancers in 3 large prospective cohort studies.European journal of epidemiology · 2023Article
- Associations of alcohol and coffee with colorectal cancer risk in East Asian populations: a Mendelian randomization study.European journal of nutrition · 2023Article
- Association of alcohol types, coffee and tea intake with mortality: prospective cohort study of UK Biobank participants.The British journal of nutrition · 2023Article
- Caffeine Limits Expansion of Apc-Deficient Clones in the Intestine by NOTUM Inhibition.Cellular and molecular gastroenterology and hepatology · 2023Article
- The therapeutic potential of matcha tea: A critical review on human and animal studies.Current research in food science · 2023Review
- Consumption of Coffee and Green Tea and the Risk of Colorectal Cancer in Korea: The Health Examinees Study.Journal of cancer prevention · 2022Article
- Elevation of Anticancer Drug Toxicity by Caffeine in Spheroid Model of Human Lung Adenocarcinoma A549 Cells Mediated by Reduction in Claudin-2 and Nrf2 Expression.International journal of molecular sciences · 2022Article
- Article
- Chemoprotective effect of boeravinone B against 1,2-dimethyl hydrazine induced colorectal cancer in rats via suppression of oxidative stress and inflammatory reaction.Journal of gastrointestinal oncology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coffee is a blend of compounds related to gastrointestinal physiology. Given its popularity and the epidemiology of colorectal cancer, the impact of this beverage on public health could be considerable. Our aim was to provide an updated synthesis of the relationship between coffee consumption and the risk of colorectal cancer. We conducted a systematic review and meta-analysis of 26 prospective studies. Regarding colorectal cancer, no significant relationship was detected. Stratifying for ethnicity, a protective effect emerged in US subjects. Concerning colon cancer, coffee proved to exert a protective effect in men and women combined and in men alone. Stratifying for ethnicity, a significant protective effect was noted in European men only and in Asian women only. Concerning rectal cancer, no association was found. Decaffeinated coffee exhibited a protective effect against colorectal cancer in men and women combined. Studies were appraised for their quality by means of the Newcastle-Ottawa Quality Assessment Scale for Cohort studies. Only one study proved to be of low quality. Ethnicity could explain the heterogeneity of the studies. However, little is known about the relationship between the genetic make-up and the risk of colorectal cancer associated with coffee. Further research is warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.