Evidence map›Paper›PMID 30909630›Full record

ReviewCancers2019

Use of Dendritic Cell Receptors as Targets for Enhancing Anti-Cancer Immune Responses.

Md Kamal Hossain, Katherine A Wall

Abstract readReview
In one paragraph

Review in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

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  11. The controversial effect of smoking and nicotine in SARS-CoV-2 infection.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023
    Review
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  16. Mannosylated Polycations Target CD206Biomacromolecules · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Md Kamal HossainDepartment of Medicinal and Biological Chemistry, University of Toledo, Toledo, 43614 OH, USA. mdkamal.hossain@rockets.utoledo.edu.
Katherine A WallDepartment of Medicinal and Biological Chemistry, University of Toledo, Toledo, 43614 OH, USA. katherine.wall@utoledo.edu.ORCID 0000-0002-1150-4736

Funding

Synthesis of Glycopeptide-Based Cancer Antigen VaccinesR15GM094734 · NIGMS · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI WALL, KATHERINE A · 2011 to 2015
$755k
NIGMS NIH HHS R15 GM094734
6 · The paper itself

Abstract

A successful anti-cancer vaccine construct depends on its ability to induce humoral and cellular immunity against a specific antigen. Targeting receptors of dendritic cells to promote the loading of cancer antigen through an antibody-mediated antigen uptake mechanism is a promising strategy in cancer immunotherapy. Researchers have been targeting different dendritic cell receptors such as Fc receptors (FcR), various C-type lectin-like receptors such as dendritic and thymic epithelial cell-205 (DEC-205), dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), and Dectin-1 to enhance the uptake process and subsequent presentation of antigen to T cells through major histocompatibility complex (MHC) molecules. In this review, we compare different subtypes of dendritic cells, current knowledge on some important receptors of dendritic cells, and recent articles on targeting those receptors for anti-cancer immune responses in mouse models.

Indexed as

C-type lectin receptordendritic cellsFc receptorimmunotherapymajor histocompatibility complex (MHC)

Identifiers

PMID30909630
PMCPMC6469018

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.