Evidence map›Paper›PMID 30909626›Full record

ArticleNanomaterials (Basel, Switzerland)2019

On-Chip Real-Time Chemical Sensors Based on Water-Immersion-Objective Pumped Whispering-Gallery-Mode Microdisk Laser.

Qijing Lu, Xiaogang Chen, Liang Fu, Shusen Xie, Xiang Wu

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Dynamics and Applications of Photon-Nanostructured Systems.Nanomaterials (Basel, Switzerland) · 2020
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Qijing LuKey Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, Provincial Key Laboratory for Photonics Technology, Institute of Laser and Optoelectronics Technology, Fujian Normal University, Fuzhou 350007, China. qjlu@fjnu.edu.cn.ORCID 0000-0001-7786-0437
Xiaogang ChenKey Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, Provincial Key Laboratory for Photonics Technology, Institute of Laser and Optoelectronics Technology, Fujian Normal University, Fuzhou 350007, China. xgchen01@139.com.
Liang FuKey Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, Provincial Key Laboratory for Photonics Technology, Institute of Laser and Optoelectronics Technology, Fujian Normal University, Fuzhou 350007, China. fuliang1995@126.com.
Shusen XieKey Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education, Provincial Key Laboratory for Photonics Technology, Institute of Laser and Optoelectronics Technology, Fujian Normal University, Fuzhou 350007, China. ssxie@fjnu.edu.cn.
Xiang WuDepartment of Optical Science and Engineering, Fudan University, Shanghai 200433, China. wuxiang@fudan.edu.cn.

Funding

Development of a Novel HCS Assay to Screen for Disruptors of AR-TIF2 InteractionsR01CA160423 · NCI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JOHNSTON, PAUL A. · 2012 to 2014
$924k
NCI CLINICAL INVESTIGATOR AWARDK08CA001267 · NCI · UNIVERSITY OF CALIFORNIA SAN DIEGO · PI GRAHAM, WILLIAM R · 1986 to 1986
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China Postdoctoral Science Foundation 2017M610389Fujian Provincial Key Project of Natural Science Foundation for Young Scientists in University JZ160423Fujian Provincial Program for Distinguished Young Scientists in University J1-1267National Key Basic Research Program of China 2015CB352006National Natural Science Foundation of China 61705039Program for Changjiang Scholars and Innovative Research Team in University IRT_15R10Special Funds of the Central Government Guiding Local Science and Technology Development 2017L3009
6 · The paper itself

Abstract

Optical whispering-gallery-mode (WGM) microresonator-based sensors with high sensitivity and low detection limit down to single unlabeled biomolecules show high potential for disease diagnosis and clinical application. However, most WGM microresonator-based sensors, which are packed in a microfluidic cell, are a "closed" sensing configuration that prevents changing and sensing the surrounding liquid refractive index (RI) of the microresonator immediately. Here, we present an "open" sensing configuration in which the WGM microdisk laser is directly covered by a water droplet and pumped by a water-immersion-objective (WIO). This allows monitoring the chemical reaction progress in the water droplet by tracking the laser wavelength. A proof-of-concept demonstration of chemical sensor is performed by observing the process of salt dissolution in water and diffusion of two droplets with different RI. This WIO pumped sensing configuration provides a path towards an on-chip chemical sensor for studying chemical reaction kinetics in real time.

Indexed as

lasermicrodisksensorwater-immersion-objective (WIO)whispering-gallery-mode (WGM)

Identifiers

PMID30909626
PMCPMC6474083

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.