Evidence map›Paper›PMID 30909606›Full record

ArticleMolecules (Basel, Switzerland)2019

Discovery of 2-Substituted 3-Arylquinoline Derivatives as Potential Anti-Inflammatory Agents Through Inhibition of LPS-Induced Inflammatory Responses in Macrophages.

Cheng-Yao Yang, Yung-Li Hung, Kai-Wei Tang, Shu-Chi Wang, Chih-Hua Tseng, Cherng-Chyi Tzeng, Po-Len Liu, Chia-Yang Li, Yeh-Long Chen

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Sasanquasaponin fromInternational journal of molecular sciences · 2024
    Article
  4. Synthesis andCurrent topics in medicinal chemistry · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Hepatoprotective Activity ofBioMed research international · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cheng-Yao YangDepartment of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung City 807, Taiwan. u102850002@kmu.edu.tw.
Yung-Li HungInstitute of Health and Sports & Medicine, Juntendo University, 1-1 Hirakagakuendai, Inzai, Chiba 270-1695, Japan. medislove@hotmail.com.
Kai-Wei TangSchool of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung City 807, Taiwan. dadaking1107@gmail.com.
Shu-Chi WangDepartment of Medical Laboratory Science and Biotechnology, Kaohsiung Medical University, Kaohsiung 807, Taiwan. shuchiwang@kmu.edu.tw.
Chih-Hua TsengSchool of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung City 807, Taiwan. chihhua@kmu.edu.tw.ORCID 0000-0001-7392-7104
Cherng-Chyi TzengDepartment of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung City 807, Taiwan. tzengch@kmu.edu.tw.
Po-Len LiuDepartment of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. kisa@kmu.edu.tw.
Chia-Yang LiGraduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 807, Taiwan. chiayangli@kmu.edu.tw.
Yeh-Long ChenDepartment of Medicinal and Applied Chemistry, College of Life Science, Kaohsiung Medical University, Kaohsiung City 807, Taiwan. yeloch@kmu.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe herein the preparation of certain 2-substituted 3-arylquinoline derivatives and the evaluation of their anti-inflammatory effects in LPS-activated murine J774A.1 macrophage cells. Among these newly synthesized 2-substituted 3-arylquinoline derivatives, 2-(4-methoxy- benzoyl)-3-(3,4,5-trimethoxyphenyl)quinoline (

Indexed as

Amino AcidsAnimalsAnti-Inflammatory AgentsHumansHydrophobic and Hydrophilic InteractionsInflammationLipopolysaccharidesMacrophagesMAP Kinase Kinase 1MiceMolecular Docking SimulationNitric OxideQuinolinesSignal TransductionTumor Necrosis Factor-alphaAmino AcidsAnti-Inflammatory AgentsLipopolysaccharidesMAP Kinase Kinase 1Nitric OxidequinolineQuinolinesTumor Necrosis Factor-alphaanti-inflammatory agentsarylquinoline derivativesinterleukin-6 (IL-6)nitric oxide (NO)tumor necrosis factor-á (TNF-á)

Identifiers

PMID30909606
PMCPMC6472047

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.