ArticleNutrients2019
Obesity Is Associated with Changes in Iron Nutrition Status and Its Homeostatic Regulation in Pregnancy.
Article in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Association between overweight/obesity and iron deficiency anaemia among women of reproductive age: a systematic review.Public health nutrition · 2024Pooled it
- The effect of prepregnancy body mass index on maternal micronutrient status: a meta-analysis.Scientific reports · 2021Pooled it
- Maternal Adiposity and DNA Methylation of TfR2 and HJV Genes in Early Pregnancy: Mediating Role of Inflammation and Consequences for Iron Status.The Journal of nutrition · 2026Trial
- Maternal Adiposity and Inflammation: Risk Factors for Iron Deficiency in Pregnancy.The Journal of nutrition · 2025Trial
- Feasibility Study ofNutrients · 2023Trial
- Maternal Overweight and Obesity during Pregnancy Are Associated with Neonatal, but Not Maternal, Hepcidin Concentrations.The Journal of nutrition · 2021Trial
- Association between Adiposity and Iron Status in Women of Reproductive Age: Data from the UK National Diet and Nutrition Survey (NDNS) 2008-2019.The Journal of nutrition · 2024Article
- Article
- Hepcidin across pregnancy and its correlation with maternal markers of iron and inflammation, maternal body weight outcomes, and offspring neurodevelopmental outcomes: a systematic review and meta-analysis.AJOG global reports · 2023Review
- Iron Deficiency and Iron Deficiency Anemia in Women with and without Obesity: NHANES 2001-2006.Nutrients · 2023Article
- Association of Pre-Pregnancy Obesity and COVID-19 with Poor Pregnancy Outcome.Journal of clinical medicine · 2023Article
- Inflammatory-Metal Profile as a Hallmark for COVID-19 Severity During Pregnancy.Frontiers in cell and developmental biology · 2022Article
- Associations of the pre-pregnancy weight status with anaemia and the erythropoiesis-related micronutrient status.Public health nutrition · 2021Article
- Nutritional Health Education in Pregnant Women in a Rural Health Centre: Results in Spanish and Foreign Women.Healthcare (Basel, Switzerland) · 2021Article
- Are Pregnant Women Who Are Living with Overweight or Obesity at Greater Risk of Developing Iron Deficiency/Anaemia?Nutrients · 2021Review
- Effect of Maternal Nutritional Status and Mode of Delivery on Zinc and Iron Stores at Birth.Nutrients · 2021Article
- Article
- Iron absorption during pregnancy is underestimated when iron utilization by the placenta and fetus is ignored.The American journal of clinical nutrition · 2020Article
- Prevalence of Hypoproteinemia and Hypoalbuminemia in Pregnant Women from Three Different Socioeconomic Populations.International journal of environmental research and public health · 2020Observational
- Iron overload is related to elevated blood glucose levels in obese children and aggravates high glucose-induced endothelial cell dysfunction in vitro.BMJ open diabetes research & care · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
The influence of obesity on maternal iron homeostasis and nutrition status during pregnancy remains only partially clarified. Our study objectives were (1) to describe how obesity influences broad iron nutrition spectrum biomarkers such as available or circulating iron (serum transferrin receptor (sTfr) and serum iron), iron reserves (ferritin), and functional iron (hemoglobin); and (2) to depict the regulating role of hepcidin. The above was carried out while considering influential factors such as initial iron nutrition status, iron intake, and the presence of inflammation. Ninety three non-anemic pregnant adult women were included, 40 with obesity (Ob) and 53 with adequate weight (AW); all took ≈30 mg/day of supplementary iron. Information on iron intake and blood samples were obtained at gestational weeks 13, 20, 27, and 35. A series of repeated measure analyses were performed using General Linear Models to discern the effect of obesity on each iron indicator; iron intake, hepcidin, and C-reactive protein were successively introduced as covariates. Available and circulating iron was lower in obese women: sTfr was higher (p = 0.07) and serum iron was lower (p = 0.01); and ferritin and hemoglobin were not different between groups. Hepcidin was higher in the Ob group (p = 0.01) and was a significant predictor variable for all biomarkers. Obesity during pregnancy dysregulates iron homeostasis, resembling "obesity hypoferremia".
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.