Evidence map›Paper›PMID 30909541›Full record

ArticleMolecules (Basel, Switzerland)2019

Synthesis and Biological Evaluation of Fangchinoline Derivatives as Anti-Inflammatory Agents through Inactivation of Inflammasome.

Ting Liu, Qingxuan Zeng, Xiaoqiang Zhao, Wei Wei, Yinghong Li, Hongbin Deng, Danqing Song

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ting LiuInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. lutyliu@126.com.
Qingxuan ZengInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. zqx50810793@163.com.
Xiaoqiang ZhaoInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. xiaoqiangzhao2017@126.com.
Wei WeiInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. weiwei082695@163.com.
Yinghong LiInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. liyinghong@imb.pumc.edu.cn.
Hongbin DengInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. hdeng@imb.pumc.edu.cn.ORCID 0000-0002-4398-8819
Danqing SongInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China. songdanqingsdq@hotmail.com.
Chinese Academy of Medical Sciences & Peking Union Medical College · CN

Funding

CAMS initiative for innovative medicine 2016-12M-3-009National Natural Science Foundation of China 81321004 and 81473248
6 · The paper itself

Abstract

Twenty eight 7-substitued fangchinoline analogues, of which twenty two were novel, were synthesized and evaluated for their effect to inhibit lipopolysaccharide/nigericin (LPS/NIG)-induced IL-1β release at both cell and protein levels at the concentration of 5 μM. Among them, compound

Indexed as

Anti-Inflammatory AgentsBenzylisoquinolinesCaspase 1Cell LineGene Expression RegulationHumansInflammasomesInflammationInterleukin-1betaLipopolysaccharidesNF-kappa BNigericinNLR Family, Pyrin Domain-Containing 3 ProteinTranscription Factor RelAAnti-Inflammatory AgentsBenzylisoquinolinesCaspase 1fangchinolineInflammasomesInterleukin-1betaLipopolysaccharidesNF-kappa BNigericinNLR Family, Pyrin Domain-Containing 3 ProteinRELA protein, humanTranscription Factor RelAAnti-inflammatoryfangchinolineIL-1βNLRP3 inflammasome

Identifiers

PMID30909541
PMCPMC6470529
OpenAlexW2923807787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.