Evidence map›Paper›PMID 30909444›Full record

ArticleCells2019

N-Glycomic and Transcriptomic Changes Associated with CDX1 mRNA Expression in Colorectal Cancer Cell Lines.

Stephanie Holst, Jennifer L Wilding, Kamila Koprowska, Yoann Rombouts, Manfred Wuhrer

Open access · goldAbstract read
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Regulation of the Lewis Blood Group Antigen Expression: A Literature Review Supplemented with Computational Analysis.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2024
    Review
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  4. Label-Free Liquid Chromatography-Mass Spectrometry Quantitation of RelativeInternational journal of molecular sciences · 2024
    Article
  5. The Assessment ofActa medica Lituanic · 2024
    Article
  6. Article
  7. In-Depth Analysis of theInternational journal of molecular sciences · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. International journal of molecular sciences · 2020
    Article
  16. Serum Protein N-Glycans in Colostrum and Mature Milk of Chinese Mothers.Journal of agricultural and food chemistry · 2020
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Stephanie HolstCenter for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. stephanie.holst@gmx.net.ORCID 0000-0002-5303-0428
Jennifer L WildingCancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, Department of Oncology, University of Oxford, Oxford OX3 9DS, UK. wildingjl@gmail.com.
Kamila KoprowskaCancer and Immunogenetics Laboratory, Weatherall Institute of Molecular Medicine, Department of Oncology, University of Oxford, Oxford OX3 9DS, UK. kamila.koprowska@gmail.com.
Yoann RomboutsCenter for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. yoann.rombouts@ipbs.fr.ORCID 0000-0003-4482-2199
Manfred WuhrerCenter for Proteomics and Metabolomics, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands. m.wuhrer@lumc.nl.ORCID 0000-0002-0814-4995
Leiden University Medical Center · NLUniversity of Oxford · GBCentre National de la Recherche Scientifique · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The caudal-related homeobox protein 1 (CDX1) is a transcription factor, which is important in the development, differentiation, and homeostasis of the gut. Although the involvement of CDX genes in the regulation of the expression levels of a few glycosyltransferases has been shown, associations between glycosylation phenotypes and CDX1 mRNA expression have hitherto not been well studied. Triggered by our previous study, we here characterized the

Indexed as

Gene Expression Regulation, NeoplasticGlycomicsCell Line, TumorColorectal NeoplasmsFucoseGlycosylationHexosaminesHomeodomain ProteinsHumansLewis Blood Group AntigensN-Acetylneuraminic AcidPhenotypePolysaccharidesPrincipal Component AnalysisRNA, MessengerTranscriptomeCDX1 protein, humanFucoseHexosaminesHomeodomain ProteinsLewis Blood Group AntigensN-Acetylneuraminic AcidPolysaccharidesRNA, Messengercaudal-related homeobox protein 1 (CDX1), differentiationcolorectal cancer cell linesfucosylationfucosyltransferase (FUT), hepatocyte nuclear factor (HNF)4AHNF1AN-glycosylation

Identifiers

PMID30909444
PMCPMC6468459
OpenAlexW2924764084

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.