Evidence map›Paper›PMID 30909423›Full record

ReviewMicromachines2019

Development of the Troponin Detection System Based on the Nanostructure.

Taek Lee, Jae-Hyuk Ahn, Jinha Choi, Yeonju Lee, Jin-Myung Kim, Chulhwan Park, Hongje Jang, Tae-Hyung Kim, Min-Ho Lee

Open access · goldAbstract readReview
In one paragraph

Review in Micromachines, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Taek LeeDepartment of Chemical Engineering, Kwangwoon University, Wolgye-dong, Nowon-gu, Seoul 01899, Korea. nanotlee@gmail.com.
Jae-Hyuk AhnDepartment of Electronic Engineering, Kwangwoon University, Wolgye-dong, Nowon-gu, Seoul 01899, Korea. jaehahn@kw.ac.kr.
Jinha ChoiDepartment of Chemical and Biomolecular Engineering, Sogang University, 35 Baekbeom-ro (Sinsu-dong), Mapo-gu, Seoul 04107, Korea. jinhachoi2@gmail.com.
Yeonju LeeDepartment of Chemical Engineering, Kwangwoon University, Wolgye-dong, Nowon-gu, Seoul 01899, Korea. mlpad@naver.com.
Jin-Myung KimDepartment of Chemical Engineering, Kwangwoon University, Wolgye-dong, Nowon-gu, Seoul 01899, Korea. wls629@icloud.com.
Chulhwan ParkDepartment of Chemical Engineering, Kwangwoon University, Wolgye-dong, Nowon-gu, Seoul 01899, Korea. chpark@kw.ac.kr.
Hongje JangDepartment of Chemistry, Kwangwoon University, Wolgye-dong, Nowon-gu, Seoul 01899, Korea. hjang@kw.ac.kr.
Tae-Hyung KimSchool of Integrative Engineering, Chung-Ang University, Heukseok-dong, Dongjak-gu, Seoul 06974, Korea. thkim@cau.ac.kr.
Min-Ho LeeSchool of Integrative Engineering, Chung-Ang University, Heukseok-dong, Dongjak-gu, Seoul 06974, Korea. mhlee7@cau.ac.kr.ORCID 0000-0002-7028-4745
Kwangwoon University · KRChung-Ang University · KRSogang University · KR

Funding

and by the Ministry of Trade, Industry, and Economy (Grant number 10062995) Grant number 10062995This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2018R1D1A1B07049407) 2018R1D1A1B07049407
6 · The paper itself

Abstract

During the last 30 years, the World Health Organization (WHO) reported a gradual increase in the number of patients with cardiovascular disease (CVD), not only in developed but also in developing countries. In particular, acute myocardial infarction (AMI) is one of the severe CVDs because of the high death rate, damage to the body, and various complications. During these harmful effects, rapid diagnosis of AMI is key for saving patients with CVD in an emergency. The prompt diagnosis and proper treatment of patients with AMI are important to increase the survival rate of these patients. To treat patients with AMI quickly, detection of a CVD biomarker at an ultra-low concentration is essential. Cardiac troponins (cTNs), cardiac myoglobin (cMB), and creatine kinase MB are typical biomarkers for AMI detection. An increase in the levels of those biomarkers in blood implies damage to cardiomyocytes and thus is related to AMI progression. In particular, cTNs are regarded as a gold standard biomarker for AMI diagnosis. The conventional TN detection system for detection of AMI requires long measurement time and is labor-intensive and tedious. Therefore, the demand for sensitive and selective TN detection techniques is increasing at present. To meet this demand, several approaches and methods have been applied to develop a TN detection system based on a nanostructure. In the present review, the authors reviewed recent advances in TN biosensors with a focus on four detection systems: (1) An electrochemical (EC) TN nanobiosensor, (2) field effect transistor (FET)-based TN nanobiosensor, (3) surface plasmon resonance (SPR)-based TN nanobiosensor and (4) surface enhanced Raman spectroscopy (SERS)-based TN nanobiosensor.

Indexed as

acute myocardial infarctioncardiac troponin detection systemelectrochemicalfield effect transistornanostructuresurface enhanced Raman spectroscopysurface plasmon resonance

Identifiers

PMID30909423
PMCPMC6470505
OpenAlexW2923884142

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.