Evidence map›Paper›PMID 30909387›Full record

ReviewInternational journal of molecular sciences2019

Mechanisms of Chemotherapy-Induced Peripheral Neuropathy.

Renata Zajączkowska, Magdalena Kocot-Kępska, Wojciech Leppert, Anna Wrzosek, Joanna Mika, Jerzy Wordliczek

3 registry-linked trialsOpen access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 396 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
396citing papers in PubMed, 8 pooled it
33.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05247840 not yet recruitingnot on this mapstarted 2022, after this paper: background citation

INvesTigation the Abnormality of Detrusor ConTractility by Uroflowmetry in Diabetic Children (INTACT Trial) - a Prospective, Cross-sectional, Observational, Controlled Study

TypeobservationalSponsorHeim Pal Children's HospitalRan2022 to 2027Enrolled350ConditionsDiabetes MellitusArmsuroflowmetry, Cardiovascular autonomic dysfunction test proposed by Ewing et al., peripheral nerve conduction test
NCT05904340 narecruitingnot on this mapstarted 2023, after this paper: background citation

The Efficacy of Social Media Assisted Home-based Transcutaneous Electrical Acupoint Stimulation on Symptoms Associated with Chemotherapy Induced Peripheral Neuropathy in Patients with Breast Cancer

TypeinterventionalSponsorNational Taipei University of Nursing and Health SciencesRan2023 to 2025Enrolled86ConditionsBreast Neoplasms, Chemotherapy-induced Peripheral NeuropathyArmsTranscutaneous Electrical Nerve Stimulation
NCT07499882 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Observational and Data Collection Study About Intrathecal Ziconotide in the Treatment of Chemotherapy Induced Neuropathy

TypeobservationalSponsorChristian Hospital Northeast NorthwestRan2026 to 2028Enrolled24ConditionsChemotherapy Induced Peripheral Neuropathy (CIPN)ArmsZiconotide
3 · Its place in the literature

Who cites it

396 citing papers in PubMed, 8 syntheses or guidelines pooled it, 775 citations in OpenAlex.

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336 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Renata ZajączkowskaDepartment of Interdisciplinary Intensive Care, Jagiellonian University, Medical College, 31-501 Krakow, Poland. renia356@poczta.onet.pl.ORCID 0000-0003-3511-5169
Magdalena Kocot-KępskaDepartment of Pain Research and Treatment, Jagiellonian University, Medical College, 31-501 Krakow, Poland. makoco@wp.pl.ORCID 0000-0002-0392-2583
Wojciech LeppertChair and Department of Palliative Medicine Poznan University of Medical Sciences, 61-245 Poznan, Poland. wojciechleppert@wp.pl.ORCID 0000-0003-0852-2535
Anna WrzosekDepartment of Interdisciplinary Intensive Care, Jagiellonian University, Medical College, 31-501 Krakow, Poland. surmiatko@interia.pl.ORCID 0000-0002-7802-1325
Joanna MikaInstitute of Pharmacology, Polish Academy of Sciences, Department of Pain Pharmacology, 31-343 Krakow, Poland. joasia272@onet.eu.
Jerzy WordliczekDepartment of Interdisciplinary Intensive Care, Jagiellonian University, Medical College, 31-501 Krakow, Poland. j.wordliczek@uj.edu.pl.ORCID 0000-0001-9969-6172
Jagiellonian University · PLMaj Institute of Pharmacology · PLPoznan University of Medical Sciences · PL

Funding

Instytut Farmakologii, Polskiej Akademii Nauk -Uniwersytet Jagielloński Collegium Medicum -Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu -
6 · The paper itself

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is one of the most frequent side effects caused by antineoplastic agents, with a prevalence from 19% to over 85%. Clinically, CIPN is a mostly sensory neuropathy that may be accompanied by motor and autonomic changes of varying intensity and duration. Due to its high prevalence among cancer patients, CIPN constitutes a major problem for both cancer patients and survivors as well as for their health care providers, especially because, at the moment, there is no single effective method of preventing CIPN; moreover, the possibilities of treating this syndrome are very limited. There are six main substance groups that cause damage to peripheral sensory, motor and autonomic neurons, which result in the development of CIPN: platinum-based antineoplastic agents, vinca alkaloids, epothilones (ixabepilone), taxanes, proteasome inhibitors (bortezomib) and immunomodulatory drugs (thalidomide). Among them, the most neurotoxic are platinum-based agents, taxanes, ixabepilone and thalidomide; other less neurotoxic but also commonlyused drugs are bortezomib and vinca alkaloids. This paper reviews the clinical picture of CIPN and the neurotoxicity mechanisms of the most common antineoplastic agents. A better understanding of the risk factors and underlying mechanisms of CIPN is needed to develop effective preventive and therapeutic strategies.

Indexed as

AnimalsAntineoplastic AgentsAntineoplastic Agents, ImmunologicalAntineoplastic Combined Chemotherapy ProtocolsBiomarkersDNA DamageHumansNeoplasmsOxidative StressPeripheral Nervous System DiseasesPlatinumProtein Kinase InhibitorsReactive Oxygen SpeciesSignal TransductionAntineoplastic AgentsAntineoplastic Agents, ImmunologicalBiomarkersPlatinumProtein Kinase InhibitorsReactive Oxygen Speciesanticancer drugscancer painchemotherapy-induced neuropathydrug neurotoxicitypathophysiological mechanisms

Identifiers

PMID30909387
PMCPMC6471666
OpenAlexW2923697933

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.