ReviewInternational journal of environmental research and public health2019
Rethinking the Dental Amalgam Dilemma: An Integrated Toxicological Approach.
Review in International journal of environmental research and public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Biomonitoring of Occupational Exposure to Mercury Among Dental Health Workers in LMICs: A Systematic Review.International dental journal · 2026Pooled it
- Evaluation of metal ion retention in tooth structure following the removal of dental amalgam restorations: an ex vivo study.BMC oral health · 2026Article
- Human biomonitoring in support of the Minamata Convention: a case of phasing out dental amalgam.Environmental health : a global access science source · 2026Article
- Fluoride Release, Recharge, and Mass Stability of Restorative Dental Materials: An In Vitro Study.Dentistry journal · 2025Article
- Green Dentistry: State of the Art and Possible Development Proposals.Dentistry journal · 2025Review
- Mercury Concentration in Saliva and the Impact of Chewing: An Inductively Coupled Plasma Mass Spectrometry Study.Biological trace element research · 2024Article
- Awareness of Students and Dentists on Sustainability Issues, Safety of Use and Disposal of Dental Amalgam.Dentistry journal · 2023Article
- Applications of Antioxidants in Dental Procedures.Antioxidants (Basel, Switzerland) · 2022Review
- Facilitators and Barriers to Implementing Sustainability in Oral Health Care.International dental journal · 2022Article
- Minimization of Adverse Effects Associated with Dental Alloys.Materials (Basel, Switzerland) · 2022Review
- Potential Health Effects of Heavy Metals and Carcinogenic Health Risk Estimation of Pb and Cd Contaminated Eggs from a Closed Gold Mine Area in Northern Thailand.Foods (Basel, Switzerland) · 2022Article
- Autism Spectrum Disorder Initiation by Inflammation-Facilitated Neurotoxin Transport.Neurochemical research · 2022Review
- Structural Conformation Comparison of Different Clear Aligner Systems: An In Vitro Study.Dentistry journal · 2022Article
- An Alternative Explanation for Alzheimer's Disease and Parkinson's Disease Initiation from Specific Antibiotics, Gut Microbiota Dysbiosis and Neurotoxins.Neurochemical research · 2022Review
- Article
- Effects of Removal Conditions on Mercury Amount Remaining in the Oral Cavity and inside Drainage System after Removing Dental Amalgams.International journal of environmental research and public health · 2021Article
- Erythrocytes as a Model for Heavy Metal-Related Vascular Dysfunction: The Protective Effect of Dietary Components.International journal of molecular sciences · 2021Review
- Clinical characteristics of oral lichen planus and its causal context with dental restorative materials and oral health-related quality of life.BMC oral health · 2021Article
- The protective role of selenium against dental amalgam-induced intracellular oxidative toxicity through the TRPV1 channel in DBTRG glioblastoma cells.Journal of applied oral science : revista FOB · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Mercury (Hg) has been identified as one of the most toxic nonradioactive materials known to man. Although mercury is a naturally occurring element, anthropogenic mercury is now a major worldwide concern and is an international priority toxic pollutant. It also comprises one of the primary constituents of dental amalgam fillings. Even though dental mercury amalgams have been used for almost two centuries, its safety has never been tested or proven in the United States by any regulatory agency. There has been an ongoing debate regarding the safety of its use since 1845, and many studies conclude that its use exposes patients to troublesome toxicity. In this review, we present in an objective way the danger of dental amalgam to human health based on current knowledge. This dilemma is addressed in terms of an integrated toxicological approach by focusing on four mayor issues to show how these interrelate to create the whole picture: (1) the irrefutable constant release of mercury vapor from dental amalgams which is responsible for individual chronic exposure, (2) the evidence of organic mercury formation from dental amalgam in the oral cavity, (3) the effect of mercury exposure on gene regulation in human cells which supports the intrinsic genetic susceptibility to toxicant and, finally, (4) the availability of recent epidemiological data supporting the link of dental amalgams to diseases such as Alzheimer's and Parkinson.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.