Evidence map›Paper›PMID 30909158›Full record

ArticleRedox biology2019

Peperomin E and its orally bioavailable analog induce oxidative stress-mediated apoptosis of acute myeloid leukemia progenitor cells by targeting thioredoxin reductase.

Xinzhi Wang, Ming Gao, Jiyun Zhang, Ying Ma, Wenshu Qu, Jingyu Liang, Hao Wu, Hongmei Wen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Redox biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Therapeutic Benefits of Selenium in Hematological Malignancies.International journal of molecular sciences · 2022
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Xinzhi WangSchool of Pharmacy, Nanjing University of Chinese Medicine, Xianlin Avenue No. 138, Nanjing 210023, People's Republic of China. Electronic address: wxzatnj@sina.com.
Ming GaoSchool of Pharmacy, Nanjing University of Chinese Medicine, Xianlin Avenue No. 138, Nanjing 210023, People's Republic of China.
Jiyun ZhangSchool of Pharmacy, Nanjing University of Chinese Medicine, Xianlin Avenue No. 138, Nanjing 210023, People's Republic of China.
Ying MaNanjing University of Science and Technology Hospital, Nanjing University of Science and Technology, Xiaolinwei Lane No. 200, Nanjing 210094, People's Republic of China.
Wenshu QuPeople's Liberation Army Cancer Center, Nanjing Bayi Hospital, Yanggongjing Street No. 34, Nanjing 210002, People's Republic of China.
Jingyu LiangDepartment of Natural Medicinal Chemistry, China Pharmaceutical University, Tongjia Lane No.24, Nanjing 210009, People's Republic of China.
Hao WuSchool of Pharmacy, Nanjing University of Chinese Medicine, Xianlin Avenue No. 138, Nanjing 210023, People's Republic of China.
Hongmei WenSchool of Pharmacy, Nanjing University of Chinese Medicine, Xianlin Avenue No. 138, Nanjing 210023, People's Republic of China. Electronic address: njwenhm@126.com.
Nanjing University of Chinese Medicine · CN81th Hospital of PLA · CNChina Pharmaceutical University · CNNanjing University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The early immature CD34

Indexed as

Administration, OralAnimalsAntineoplastic AgentsApoptosisBenzodioxolesBiological AvailabilityBiomarkersCell Line, TumorCell ProliferationDisease Models, AnimalEnzyme ActivationFemaleHumansImmunophenotypingLeukemia, Myeloid, AcuteMiceAntineoplastic AgentsBenzodioxolesBiomarkerspeperomin EReactive Oxygen SpeciesThioredoxin-Disulfide ReductaseAcute myeloid leukemia progenitor cellsOrally bioavailable analogOxidative-mediated apoptosisPeperomin EThioredoxin reductase 1

Identifiers

PMID30909158
PMCPMC6434189
OpenAlexW2921341927

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.