Observational studyEpilepsy & behavior : E&B2019
Default mode network deactivation in pediatric temporal lobe epilepsy: Relationship to a working memory task and executive function tests.
Observational study in Epilepsy & behavior : E&B, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Brain connectivity signatures of cognitive impairment in temporal lobe epilepsy identified by robotic assessment.Neuroimage. Reports · 2026Article
- Assessing Executive Function in Patients With Temporal Lobe Epilepsy Through a Game-Based Assessment Task.Behavioural neurology · 2026Article
- The Impact of Sociodemographic Disadvantage on Cognitive Outcomes in Children With Newly Diagnosed Seizures and Their Unaffected Siblings Over 36 Months.Pediatric neurology · 2023Article
- Disorganization of language and working memory systems in frontal versus temporal lobe epilepsy.Brain : a journal of neurology · 2023Article
- Abnormal hubs in global network as neuroimaging biomarker in right temporal lobe epilepsy at rest.Frontiers in psychiatry · 2022Article
- HIV infection is linked with reduced error-related default mode network suppression and poorer medication management abilities.Progress in neuro-psychopharmacology & biological psychiatry · 2021Article
- Neurobehavioural comorbidities of epilepsy: towards a network-based precision taxonomy.Nature reviews. Neurology · 2021Review
- Disruption in Surface-Based Functional Connectivity in the Right Posterior Hippocampal CA3 Subfield: A Probable Neural Basis of Visuospatial Working Memory Impairment in Patients With Right Temporal Lobe Epilepsy.Frontiers in neurology · 2021Article
- Abnormal Degree Centrality in White Matter Hyperintensities: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in psychiatry · 2021Article
- Alterations in intra- and internetwork functional connectivity associated with levetiracetam treatment in temporal lobe epilepsy.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- The Oscillatory Basis of Working Memory Function and Dysfunction in Epilepsy.Frontiers in human neuroscience · 2020Review
- Precuneus-Dominant Degeneration of Parietal Lobe Is at Risk of Epilepsy in Mild Alzheimer's Disease.Frontiers in neurology · 2019Article
Corrections and comments
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Authors and funding
6 authors.
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Abstract
objectivesChildren with temporal lobe epilepsy (TLE) exhibit executive dysfunction on traditional neuropsychological tests. There is limited evidence of different functional network alterations associated with this clinical executive dysfunction. This study investigates working memory deficits in children with TLE by assessing deactivation of the default mode network (DMN) on functional Magnetic Resonance Imaging (fMRI) and the relationship of DMN deactivation with fMRI behavioral findings and neuropsychological test performance. EXPERIMENTAL
designfMRI was conducted on 15 children with TLE and 15 healthy controls (age: 8-16 years) while performing the N-back task in order to assess deactivation of the DMN. N-back accuracy, N-back reaction time, and neuropsychological tests of executive function (Delis-Kaplan Executive Function System [D-KEFS] Color-Word Interference and Card Sort tests) were also assessed. PRINCIPAL OBSERVATIONS: During the N-back task, children with TLE exhibited significantly less deactivation of the DMN, primarily in the precuneus/posterior cingulate cortex compared with controls. These alterations significantly correlated with N-back behavioral findings and D-KEFS results.
conclusionsChildren with TLE exhibit executive dysfunction which correlates with DMN alterations. These findings suggest that the level of deactivation of specific functional networks may contribute to cognitive impairment in children with TLE. The findings also indicate that children with TLE have network alterations in extratemporal lobe brain regions.
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