Evidence map›Paper›PMID 30909026›Full record

ArticleNeuroImage. Clinical2019

CACNA1C risk variant affects microstructural connectivity of the amygdala.

Katharina Koch, Sophia Stegmaier, Lena Schwarz, Michael Erb, Mara Thomas, Klaus Scheffler, Dirk Wildgruber, Vanessa Nieratschker, Thomas Ethofer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. CACNA1C-Related Channelopathies.Handbook of experimental pharmacology · 2023
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Katharina KochDepartment of General Psychiatry, University of Tuebingen, Tuebingen, Germany. Electronic address: Katharina.Koch@med.uni-tuebingen.de.
Sophia StegmaierDepartment of General Psychiatry, University of Tuebingen, Tuebingen, Germany.
Lena SchwarzDepartment of General Psychiatry, University of Tuebingen, Tuebingen, Germany.
Michael ErbDepartment of Biomedical Resonance, University of Tuebingen, Tuebingen, Germany.
Mara ThomasDepartment of General Psychiatry, University of Tuebingen, Tuebingen, Germany.
Klaus SchefflerDepartment of Biomedical Resonance, University of Tuebingen, Tuebingen, Germany; Max-Planck-Institute for Biological Cybernetics, University of Tuebingen, Tuebingen, Germany.
Dirk WildgruberDepartment of General Psychiatry, University of Tuebingen, Tuebingen, Germany.
Vanessa NieratschkerDepartment of General Psychiatry, University of Tuebingen, Tuebingen, Germany; Werner Reichardt Center for Integrative Neuroscience, University of Tuebingen, Tuebingen, Germany.
Thomas EthoferDepartment of General Psychiatry, University of Tuebingen, Tuebingen, Germany; Department of Biomedical Resonance, University of Tuebingen, Tuebingen, Germany.
University of Tübingen · DEMax Planck Institute for Biological Cybernetics · DESenckenberg Centre for Human Evolution and Palaeoenvironment · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Deficits in perception of emotional prosody have been described in patients with affective disorders at behavioral and neural level. In the current study, we use an imaging genetics approach to examine the impact of CACNA1C, one of the most promising genetic risk factors for psychiatric disorders, on prosody processing on a behavioral, functional and microstructural level. Using functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) we examined key areas involved in prosody processing, i.e. the amygdala and voice areas, in a healthy population. We found stronger activation to emotional than neutral prosody in the voice areas and the amygdala, but CACNA1C rs1006737 genotype had no influence on fMRI activity. However, significant microstructural differences (i.e. mean diffusivity) between CACNA1C rs1006737 risk allele carriers and non carriers were found in the amygdala, but not the voice areas. These modifications in brain architecture associated with CACNA1C might reflect a neurobiological marker predisposing to affective disorders and concomitant alterations in emotion perception.

Indexed as

AmygdalaAuditory CortexSocial PerceptionAdultBrain MappingCalcium Channels, L-TypeDiffusion Tensor ImagingEmotionsFemaleHumansMaleSpeech PerceptionYoung AdultCACNA1C protein, humanCalcium Channels, L-TypeAmygdalaAuditory cortexCACNA1CEmotion processingProsody

Identifiers

PMID30909026
PMCPMC6434179
OpenAlexW2921690070

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.