ArticleDrug and alcohol dependence2019
Trends in fentanyl and fentanyl analogue-related overdose deaths - Montgomery County, Ohio, 2015-2017.
Article in Drug and alcohol dependence, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04706624 (Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics), which is not on this map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Screen, Treat and Retain Meth-using People With Opioid Use Disorders at Methadone Clinics
Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
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- Fentanyl decreases blood oxygen more than furanylfentanyl despite similar effects on breathing.Research square · 2026Article
- Effects of orally self-administered furanyl fentanyl and acryl fentanyl in mice: antinociception, dependence and withdrawal, and defense of consumption.Neuropharmacology · 2025Article
- Characteristics of take-home fentanyl test strip use and support for drug checking services among people who use heroin in Australia: learnings for an increasingly complex drug market.Harm reduction journal · 2025Article
- Fentanyl-related deaths in Ontario, Canada: toxicological findings and circumstances of death in 4395 cases (2020-22).Journal of analytical toxicology · 2024Article
- The incidence, predictors, and causes of cardiac arrest in United States emergency departments.Resuscitation plus · 2024Article
- Endogenous and Exogenous Opioids: Role in Substance Use Disorders.Advances in neurobiology · 2024Review
- A case study for local data surveillance in opioid overdose fatalities in Cuyahoga County, OH 2016-2020.Drug and alcohol dependence reports · 2023Article
- Community overdose surveillance: Fentanyl involvement in overdose deaths in rural Michigan.Drug and alcohol dependence reports · 2023Article
- Fentanyl analog structure-activity relationships demonstrate determinants of diverging potencies for antinociception and respiratory depression.Pharmacology, biochemistry, and behavior · 2023Article
- Trajectories of non-prescribed buprenorphine and other opioid use: A multi-trajectory latent class growth analysis.Journal of substance use and addiction treatment · 2023Article
- Opioid Overdoses Increase at Home During the COVID-19 Stay-At-Home Order Period in Cook County, Illinois.AJPM focus · 2022Article
- Reports of Adverse Events Associated with Use of Novel Psychoactive Substances, 2017-2020: A Review.Journal of analytical toxicology · 2022Review
- Synthetic opioids: a review and clinical update.Therapeutic advances in psychopharmacology · 2022Review
- Tramadol in seized drugs containing non-pharmaceutical fentanyl: Crime lab data from Ohio, USA.Emerging trends in drugs, addictions, and health · 2022Article
- An alarming rise in the prevalence of deaths with methamphetamine involved in Tehran, Iran 2011-2018.Forensic science, medicine, and pathology · 2021Article
- Opioid use at the transition to emerging adulthood: A latent class analysis of non-medical use of prescription opioids and heroin use.Addictive behaviors · 2021Article
- Medical, Nonmedical, and Illegal Stimulant Use by Sexual Identity and Gender.American journal of preventive medicine · 2020Article
- Listed for sale: Analyzing data on fentanyl, fentanyl analogs and other novel synthetic opioids on one cryptomarket.Drug and alcohol dependence · 2020Article
- Determination of 37 fentanyl analogues and novel synthetic opioids in hair by UHPLC-MS/MS and its application to authentic cases.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
introductionThere is a lack of information on illicitly manufactured fentanyl and fentanyl analogue-related (IMF) unintentional overdose death trends over time. The study analyzes IMF-related unintentional overdose fatalities that occurred between July 2015 and June 2017 in Montgomery County, Ohio, an area with the highest rates of unintentional overdose mortality in Ohio.
methodsLC-MS/MS-based method was used to identify fentanyl analogs and metabolites in 724 unintentional overdose death cases. The Chi-square statistic was used to assess differences over time in demographic and drug-related characteristics.
resultsThe number of unintentional overdose death cases testing positive for IMFs increased by 377% between second half of 2015 and first half of 2017. The majority of decedents were white (82.5%) and male (67.8%). The proportion of fentanyl-only (no other analogs) cases declined from 89.2%-24.6% (p < 0.001), while proportion of fentanyl analogue-containing cases increased from 9.8%-70.3% (p < 0.001) between the second half of 2015 and first half of 2017. The most commonly identified fentanyl analogs were carfentanil (29.7%), furanyl fentanyl (14.1%) and acryl fentanyl (10.2%). Proportion of IMF cases also testing positive for heroin declined from 21.6% to 5.4% (p < 0.001), while methamphetamine positive cases increased from 1.4%-17.8% (p < 0.001) over the same time period. DISCUSSION: Emergence of fentanyl analogs contributed to substantial increases in unintentional overdose deaths. The data indicate a growing overlap between the IMF and methamphetamine outbreaks. Continuous monitoring of local IMF trends and rapid information dissemination to active users are needed to reduce the risks associated with IMF use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.