Evidence map›Paper›PMID 30909002›Full record

Trial reportGait & posture2019

Fractal analysis of gait in people with Parkinson's disease: three minutes is not enough.

Vivien Marmelat, Ryan L Meidinger

Abstract readClinical Trial
In one paragraph

Trial report in Gait & posture, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Subtle to significant: Enhancing heaviness perception with stochastic resonance.Journal of experimental psychology. Human perception and performance · 2026
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  10. Fractal Analysis in Neurodegenerative Diseases.Advances in neurobiology · 2024
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  20. Differences in reproducibility of gait variability and fractal dynamics according to walking duration.Technology and health care : official journal of the European Society for Engineering and Medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Vivien MarmelatDepartment of Biomechanics, University of Nebraska at Omaha, Omaha, Nebraska, 68184, USA. Electronic address: vmarmelat@unomaha.edu.
Ryan L MeidingerDepartment of Biomechanics, University of Nebraska at Omaha, Omaha, Nebraska, 68184, USA. Electronic address: rmeidinger@unomaha.edu.

Funding

Visual control of locomotion in people with Parkinsons diseaseP20GM109090 · NIGMS · UNIVERSITY OF NEBRASKA OMAHA · PI STERGIOU, NIKOLAOS · 2014 to 2023
$20.5M
NIGMS NIH HHS P20 GM109090
6 · The paper itself

Abstract

backgroundThe fractal dynamics of gait variability in people with Parkinson's disease has been studied by applying the detrended fluctuation analysis (DFA) to short time series (<200 strides). However, DFA is sensitive to time series length, and it is unclear if DFA results from short time series are reliable and if they reflect the fractal dynamics of longer time series. RESEARCH QUESTION: Is DFA reliable when applied to short time series?

methodsWe applied DFA to stride time series from five 3-min trials and one 15-min trial in 12 people with Parkinson's disease, 14 healthy older adults and 14 healthy young adults walking overground. Within each group, intraclass correlations (ICC 3,1) were performed to assess the reliability of i) the five 3-min trials together, ii) each 3-min trials to the 15-min trial, and iii) the first 150 strides from the 15-min trial to the full 15-min trial.

resultsOur three main findings are that 1) stride time α-DFA values are not consistent from trial-to-trial for short stride time series, 2) stride time α-DFA values from each 3-min trials are not consistent when compared to stride time α-DFA values from a 15-min trial, and 3) stride time α-DFA values from the first 150 strides of the 15-min trial are not consistent when compared to α-DFA values from the full 15-min trial. SIGNIFICANCE: Our results confirm that α-DFA values from 3-min walking trials are not reliable, and that they do not reflect the scale invariant properties of longer time series. This suggests that previous studies assessing the fractal dynamics of gait variability from about 3-min walking must be interpreted with caution. A major clinical implication is that DFA cannot be used to study gait in people unable to perform 500 strides continuously.

Indexed as

FractalsAdultAgedCase-Control StudiesFemaleGaitGait AnalysisHumansMaleMiddle AgedParkinson DiseaseReproducibility of ResultsTime FactorsYoung AdultDetrended fluctuation analysisFractal fluctuationsGait variabilityOverground walkingParkinson’s diseaseStride time series

Identifiers

PMID30909002
PMCPMC6545579

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.