Evidence map›Paper›PMID 30908966›Full record

ReviewHearing research2019

Circadian integration of inflammation and glucocorticoid actions: Implications for the cochlea.

Heela Sarlus, Jacopo Maria Fontana, Evangelia Tserga, Inna Meltser, Christopher R Cederroth, Barbara Canlon

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Hearing research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Heela SarlusDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 17177, Sweden. Electronic address: heela.sarlus@ki.se.
Jacopo Maria FontanaDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 17177, Sweden.
Evangelia TsergaDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 17177, Sweden.
Inna MeltserDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 17177, Sweden.
Christopher R CederrothDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 17177, Sweden.
Barbara CanlonDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, 17177, Sweden.
Karolinska Institutet · SE

Funding

Circadian regulation of glucocorticoid-dependent inflammation in noise-induced synaptopathyR56DC016415 · NIDCD · KAROLINSKA INSTITUTE · PI CANLON, BARBARA · 2017 to 2017
$292k
Hearing circadian rhythms.R21DC013172 · NIDCD · KAROLINSKA INSTITUTE · PI CANLON, BARBARA · 2013 to 2014
$272k
NIDCD NIH HHS R21 DC013172NIDCD NIH HHS R56 DC016415
6 · The paper itself

Abstract

Auditory function has been shown to be influenced by the circadian system. Increasing evidence point towards the regulation of inflammation and glucocorticoid actions by circadian rhythms in the cochlea. Yet, how these three systems (circadian, immune and endocrine) converge to control auditory function remains to be established. Here we review the knowledge on immune and glucocorticoid actions, and how they interact with the circadian and the auditory system, with a particular emphasis on cochlear responses to noise trauma. We propose a multimodal approach to understand the mechanisms of noise-induced hearing loss by integrating the circadian, immune and endocrine systems into the bearings of the cochlea. Considering the well-established positive impact of chronotherapeutic approaches in the treatment of cardiovascular, asthma and cancer, an increased knowledge on the mechanisms where circadian, immune and glucocorticoids meet in the cochlea may improve current treatments against hearing disorders.

Indexed as

Drug ChronotherapyAnimalsAnti-Inflammatory AgentsCochleaGlucocorticoidsHearingHearing Loss, Noise-InducedHumansInflammationInflammation MediatorsNoiseAnti-Inflammatory AgentsGlucocorticoidsInflammation MediatorsCircadianCochleaGlucocorticoidsHearing lossImmune systemInflammation

Identifiers

PMID30908966
PMCPMC6855252
OpenAlexW2921923702

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.