Evidence map›Paper›PMID 30908942›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2019

B-lymphocyte-intrinsic and -extrinsic defects in secretory immunoglobulin A production in the neural crest-conditional deletion of endothelin receptor B model of Hirschsprung-associated enterocolitis.

Giuliana Medrano, Frederic Cailleux, Peihong Guan, Korah Kuruvilla, Amanda J Barlow-Anacker, Ankush Gosain

Open access · bronzeAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. ET-3/ETBR Mediates NaCirculation research · 2025
    Article
  6. Article
  7. Hirschsprung-associated enterocolitis: a comprehensive review.World journal of pediatric surgery · 2024
    Review
  8. Update on the Pathogenesis of the Hirschsprung-Associated Enterocolitis.International journal of molecular sciences · 2023
    Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Giuliana MedranoDivision of Pediatric Surgery, Department of Surgery, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.
Frederic CailleuxDivision of Pediatric Surgery, Department of Surgery, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.
Peihong GuanDivision of Pediatric Surgery, Department of Surgery, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.
Korah KuruvillaDivision of Pediatric Surgery, Department of Surgery, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.
Amanda J Barlow-AnackerDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Ankush GosainDivision of Pediatric Surgery, Department of Surgery, University of Tennessee Health Sciences Center, Memphis, Tennessee, USA.
University of Tennessee Health Science Center · USUniversity of Wisconsin–Madison · US

Funding

Gastrointestinal Mucosal Immune Defects in Hirschsprungs DiseaseK08DK098271 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI GOSAIN, ANKUSH · 2014 to 2018
$815k
Validating Intestinal Enteroids to Study Hirschsprung's Associated EnterocolitisR03DK114543 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI GOSAIN, ANKUSH · 2017 to 2018
$152k
NIDDK NIH HHS K08 DK098271NIDDK NIH HHS R03 DK114543
6 · The paper itself

Abstract

Hirschsprung disease (HSCR) is a common cause of intestinal obstruction in the newborn. Hirschsprung-associated enterocolitis (HAEC) is a significant and life-threatening complication of HSCR, affecting up to 60% of patients. Animal models of endothelin receptor B (

Indexed as

Sequence DeletionAnimalsB-LymphocytesDisease Models, AnimalEnterocolitisFemaleHirschsprung DiseaseImmunoglobulin A, SecretoryMaleMiceMice, KnockoutNeural CrestReceptor, Endothelin BSpleenImmunoglobulin A, SecretoryReceptor, Endothelin BaganglionosisIgAmegacolonmucosal immunitypolymeric Ig receptor

Identifiers

PMID30908942
PMCPMC6529339
OpenAlexW2922574819

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.