Evidence map›Paper›PMID 30908934›Full record

ArticleAmerican journal of physiology. Renal physiology2019

Heritability and individuality of the plasma sodium concentration: a twin study in the United States veteran population.

Andrew K Timmons, Anna M Korpak, Jenny Tan, Kathryn P Moore, Cindy H Liu, Christopher W Forsberg, Jack Goldberg, Nicholas L Smith, David M Cohen

Open access · bronzeAbstract readTwin Study
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Andrew K TimmonsEpidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington.
Anna M KorpakEpidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington.
Jenny TanEpidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington.
Kathryn P MooreEpidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington.
Cindy H LiuEpidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington.
Christopher W ForsbergEpidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, Washington.
Jack GoldbergDepartment of Epidemiology, University of Washington , Seattle, Washington.
Nicholas L SmithDepartment of Epidemiology, University of Washington , Seattle, Washington.
David M CohenDivision of Nephrology and Hypertension, Department of Medicine, Oregon Health & Science University , Portland, Oregon.
University of Puget Sound · USUniversity of Washington · USVA Portland Health Care System · US

Funding

Genetic determinants of water balance in the elderlyR21AG029968 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI COHEN, DAVID M · 2008 to 2009
$284k
A Novel Locus in the Regulation of Human Water BalanceI01BX003449 · VA · PORTLAND VA MEDICAL CENTER · PI COHEN, DAVID M · 2018 to 2022
–
BLRD VA I01 BX003449NIA NIH HHS R21 AG029968
6 · The paper itself

Abstract

Little is known about the population genetics of water balance. A recent meta-genome-wide association study on plasma sodium concentration identified novel loci of high biological plausibility, yet heritability of the phenotype has never been convincingly shown in European ancestry. The present study linked the Vietnam Era Twin Registry with the Department of Veterans Affairs VistA patient care clinical database. Participants (

Indexed as

Genetic HeterogeneityHeredityVeteransBiological Variation, IndividualBlack or African AmericanDatabases, FactualGenetics, PopulationGlomerular Filtration RateHumansMaleMiddle AgedRegistriesSodiumTwins, DizygoticTwins, MonozygoticUnited StatesSodiumgeneticshumanhypernatremiahyponatremiawater

Identifiers

PMID30908934
PMCPMC6842886
OpenAlexW2928796661

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.