Evidence map›Paper›PMID 30908777›Full record

ArticleJournal of veterinary internal medicine2019

Randomized field trial on the effects of body weight and short transport on stress and immune variables in 2- to 4-week-old dairy calves.

Christien Masmeijer, Bert Devriendt, Tina Rogge, Katharina van Leenen, Lieze De Cremer, Bonny Van Ranst, Piet Deprez, Eric Cox, Bart Pardon

Open access · goldAbstract readClinical Trial, Veterinary
In one paragraph

Article in Journal of veterinary internal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
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  6. Article
  7. Welfare of cattle during transport.EFSA journal. European Food Safety Authority · 2022
    Article
  8. Male dairy calf welfare: A Canadian perspective on challenges and potential solutions.The Canadian veterinary journal = La revue veterinaire canadienne · 2022
    Review
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 4 countries.

Christien MasmeijerDepartment of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.ORCID https://orcid.org/0000-0001-7371-6219
Bert DevriendtLaboratory of Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.
Tina RoggeProviron Industries NV, Georges Gilliotstraat 60, Hemiksem, Belgium.
Katharina van LeenenDepartment of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.ORCID https://orcid.org/0000-0002-4889-5734
Lieze De CremerDepartment of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.
Bonny Van RanstVan Ranst Dairy farm, Zeutestraat 3, Puurs, Belgium.
Piet DeprezDepartment of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.
Eric CoxLaboratory of Immunology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.
Bart PardonDepartment of Large Animal Internal Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, Merelbeke, Belgium.ORCID https://orcid.org/0000-0003-1026-8433
Ghent University · BEClínica Girona · ESZen-Noh (Japan) · JP

Funding

Baekeland grant IWT.150705
6 · The paper itself

Abstract

backgroundWhether underweight calves respond differently to transport stress, enhancing their disease risk, is currently unknown.

objectiveTo determine the effects of low body weight and transport stress on immune variables. ANIMALS: Twenty-one 2- to 4-week-old male Holstein calves, housed on a commercial farm.

methodsRandomized clinical trial. Full factorial design with 4 treatment groups: low body weight (≤46 kg)/no transport (LOWCON); low body weight/transport (LOWTRANS); normal body weight (>46 kg)/no transport (NORMCON), and normal body weight/transport (NORMTRANS). Transport duration was 2 hours.

resultsTransport significantly increased serum cortisol concentration (77.8 μg/mL; 95% confidence interval [CI], 37.8-131.6; P < .001), interleukin (IL)-17A (344.9 pg/mL; 95% CI, 32.2-556.5; P = .04), and tumor necrosis factor-α (TNF-α) (218.2 pg/mL; 95% CI, 32.5-368.3; P = .03) production after lipopolysaccharide (LPS) stimulation. Body weight did not affect any of the studied variables. However, the interaction of transport and body weight was significant. LOWTRANS calves showed increased monocyte count (2.0 × 10 CONCLUSION AND CLINICAL IMPORTANCE: These findings contribute to our understanding of increased disease susceptibility of underweight calves when transported. Gamma globulin concentration was identified as important interfering factor in studies on immune variables in neonatal calves.

Indexed as

TransportationAnimalsBody WeightCattleCattle DiseasesHydrocortisoneInterleukin-17Leukocytes, MononuclearLipopolysaccharidesMaleRandom AllocationStress, PhysiologicalTumor Necrosis Factor-alphaHydrocortisoneInterleukin-17LipopolysaccharidesTumor Necrosis Factor-alphacortisolmodulated leukocyte functionspreweaned calvesrespiratory diseasewelfare

Identifiers

PMID30908777
PMCPMC6524119
OpenAlexW2946645783

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.