Observational studyInternational journal of geriatric psychiatry2019
Cardiovascular health and dementia incidence among older adults in Latin America: Results from the 10/66 study.
Observational study in International journal of geriatric psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cardiovascular Health, 2010 to 2020: A Systematic Review of a Decade of Research on Life's Simple 7.Journal of the American Heart Association · 2025Pooled it
- A systematic review and meta-analysis of the association between cardiovascular health determined by life's essential 8 and risk of mortality and major non-communicable diseases.Frontiers in cardiovascular medicine · 2025Pooled it
- Impact of mid-life cardiovascular health on cognitive change in a bi-ethnic cohort.medRxiv : the preprint server for health sciences · 2025Article
- Modifiable dementia risk factors in Chilean adults are distinctively associated with social determinants of health. Cross-sectional study.BMC public health · 2025Article
- Predictors of cognitive change in cognitively healthy older women in Panama: the PARI-HD study.Frontiers in global women's health · 2024Article
- Risk of mild cognitive impairment among older adults in the United States by ethnoracial group.International psychogeriatrics · 2021Article
- Current trends and challenges on dementia management and research in Latin America.Journal of global health · 2020Review
- Risk Factors for Incident Dementia Among Older Cubans.Frontiers in public health · 2020Article
- Cardiovascular contributions to dementia: beyond individual risk factors.International psychogeriatrics · 2019Article
- Current perspectives on prevention of vascular cognitive impairment and promotion of vascular brain health.Expert review of neurotherapeuticsReview
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectivesGrowing evidence shows that cardiovascular health (CVH) is associated with brain health. Little is known about this topic among older adults in Latin America, where the number of people living with dementia is rising. This study aimed to assess the longitudinal association between CVH and dementia in six Latin American countries.
methodsWe analyzed longitudinal data from the 10/66 study that included nondementia residents at baseline aged 65+ in six Latin American countries (n = 6447) and were followed up for 3 years. An index of modifiable CVH factors (ranging from 0 to 14) was calculated. Incident dementia was modeled using competing risk regression to adjust for risk of death.
resultsThe sample included 6.2% participants with poor (0-5), 81.0% with moderate (6-10), and 12.8% with ideal CVH (11-14). At follow-up, 9.4% had developed dementia and 13.1% had died. Compared with those with poor CVH, participants with moderate and ideal levels of CVH had a significantly lower risk of dementia in both the unadjusted (subhazard ratio for moderate, 0.77; ideal, 0.59) and adjusted models (moderate, 0.73; ideal, 0.66).
conclusionModerate and ideal levels of CVH in old age may protect against dementia incidence. These findings may inform health promotion efforts within dementia national plans adopted recently in some Latin American countries.
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