Trial reportPloS one2019
Impact of improved attenuation correction on 18F-FDG PET/MR hybrid imaging of the heart.
Trial report in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- A review of PET attenuation correction methods for PET-MR.EJNMMI physics · 2023Review
- Intra-Individual Comparison ofCancers · 2022Article
- Procedural recommendations of cardiac PET/CT imaging: standardization in inflammatory-, infective-, infiltrative-, and innervation (4Is)-related cardiovascular diseases: a joint collaboration of the EACVI and the EANM.European journal of nuclear medicine and molecular imaging · 2021Article
- MR-based Attenuation Correction for Brain PET Using 3D Cycle-Consistent Adversarial Network.IEEE transactions on radiation and plasma medical sciences · 2021Article
- Attenuation correction for human PET/MRI studies.Physics in medicine and biology · 2020Article
- Evaluation of improved attenuation correction in whole-body PET/MR on patients with bone metastasis using various radiotracers.European journal of nuclear medicine and molecular imaging · 2020Article
- PET/MRI attenuation estimation in the lung: A review of past, present, and potential techniques.Medical physics · 2020Review
- Evaluation of 511 keV photon attenuation by a novel 32-channel phased array prospectively designed for cardiovascular hybrid PET/MRI imaging.European journal of hybrid imaging · 2020Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of this study was to evaluate and quantify the effect of improved attenuation correction (AC) including bone segmentation and truncation correction on 18F-Fluordesoxyglucose cardiac positron emission tomography/magnetic resonance (PET/MR) imaging.
methodsPET data of 32 cardiac PET/MR datasets were reconstructed with three different AC-maps (1. Dixon-VIBE only, 2. HUGE truncation correction and bone segmentation, 3. MLAA). The Dixon-VIBE AC-maps served as reference of reconstructed PET data. 17-segment short-axis polar plots of the left ventricle were analyzed regarding the impact of each of the three AC methods on PET quantification in cardiac PET/MR imaging. Non-AC PET images were segmented to specify the amount of truncation in the Dixon-VIBE AC-map serving as a reference. All AC-maps were evaluated for artifacts.
resultsUsing HUGE + bone AC results in a homogeneous gain of ca. 6% and for MLAA 8% of PET signal distribution across the myocardium of the left ventricle over all patients compared to Dixon-VIBE AC only. Maximal relative differences up to 18% were observed in segment 17 (apex). The body volume truncation of -12.7 ± 7.1% compared to the segmented non-AC PET images using the Dixon-VIBE AC method was reduced to -1.9 ± 3.9% using HUGE and 7.8 ± 8.3% using MLAA. In each patient, a systematic overestimation in AC-map volume was observed when applying MLAA. Quantitative impact of artifacts showed regional differences up to 6% within single segments of the myocardium.
conclusionsImproved AC including bone segmentation and truncation correction in cardiac PET/MR imaging is important to ensure best possible diagnostic quality and PET quantification. The results exhibited an overestimation of AC-map volume using MLAA, while HUGE resulted in a more realistic body contouring. Incorporation of bone segmentation into the Dixon-VIBE AC-map resulted in homogeneous gain in PET signal distribution across the myocardium. The majority of observed AC-map artifacts did not significantly affect the quantitative assessment of the myocardium.
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