ArticlePLoS biology2019
Performing group-level functional image analyses based on homologous functional regions mapped in individuals.
Article in PLoS biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
72 citing papers in PubMed, 125 citations in OpenAlex.
- Accelerated intermittent theta burst stimulation targeting personalized fronto-parietal control network improves core symptoms of autism spectrum disorder: a double-blind, randomized controlled trial.Molecular psychiatry · 2026Trial
- Selective KOR antagonist alters functional patch sizes in individualized brain system: results from the Fast-fail Trial in Mood and Anxiety Spectrum Disorders (FAST-MAS).Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Trial
- Individualized Functional Brain System Topologies and Major Depression: Relationships Among Patch Sizes and Clinical Profiles and Behavior.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Trial
- Subthalamic Nucleus Deep Brain Stimulation Modulates 2 Distinct Neurocircuits.Annals of neurology · 2020Trial
- Preserved intrinsic neural timescale organization with hierarchical variation in autism spectrum disorder.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- A cortical gradient in area 55b links language and somato-cognitive action networks.Research square · 2026Article
- Personalized functional topography-based multisite brain age prediction modeling reveals divergent neurodevelopment in major depression.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Individual-specific functional connectivity predicts clinical symptoms severity in patients with post-traumatic stress disorder.BMC psychiatry · 2026Article
- Article
- Commonality and Variability in Functional Networks in Children Under 5 Years Old.bioRxiv : the preprint server for biology · 2026Article
- Clinical patterns in a neuroimaging-based predictive model of self-reported dissociation.Journal of psychiatric research · 2026Article
- Individualized functional brain mapping machine learning prediction of symptom-change resulting from selective kappa-opioid antagonism in an anhedonic sample from a Fast-Fail trial.Journal of mood and anxiety disorders · 2025Article
- Development of areal-level individualized homologous functional parcellations in youth.Communications biology · 2025Article
- Action-mode subnetworks for decision-making, action control, and feedback.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The generalizability of cortical area parcellations across early childhood.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Mapping individualized multi-scale hierarchical brain functional networks from fMRI by self-supervised deep learning.bioRxiv : the preprint server for biology · 2025Article
- Human lifespan changes in the brain's functional connectome.Nature neuroscience · 2025Article
- Connectional axis of individual functional variability: Patterns, structural correlates, and relevance for development and cognition.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Connectional axis of individual functional variability: Patterns, structural correlates, and relevance for development and cognition.bioRxiv : the preprint server for biology · 2025Article
- Individual connectivity-based parcellations reflect functional properties of human auditory cortex.Imaging neuroscience (Cambridge, Mass.) · 2025Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 7 institutions in 4 countries.
Funding
Abstract
Functional MRI (fMRI) studies have traditionally relied on intersubject normalization based on global brain morphology, which cannot establish proper functional correspondence between subjects due to substantial intersubject variability in functional organization. Here, we reliably identified a set of discrete, homologous functional regions in individuals to improve intersubject alignment of fMRI data. These functional regions demonstrated marked intersubject variability in size, position, and connectivity. We found that previously reported intersubject variability in functional connectivity maps could be partially explained by variability in size and position of the functional regions. Importantly, individual differences in network topography are associated with individual differences in task-evoked activations, suggesting that these individually specified regions may serve as the "localizer" to improve the alignment of task-fMRI data. We demonstrated that aligning task-fMRI data using the regions derived from resting state fMRI may lead to increased statistical power of task-fMRI analyses. In addition, resting state functional connectivity among these homologous regions is able to capture the idiosyncrasies of subjects and better predict fluid intelligence (gF) than connectivity measures derived from group-level brain atlases. Critically, we showed that not only the connectivity but also the size and position of functional regions are related to human behavior. Collectively, these findings suggest that identifying homologous functional regions across individuals can benefit a wide range of studies in the investigation of connectivity, task activation, and brain-behavior associations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.