ArticleJournal of pediatric gastroenterology and nutrition2019
Clinically Evident Portal Hypertension: An Operational Research Definition for Future Investigations in the Pediatric Population.
Article in Journal of pediatric gastroenterology and nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Accuracy of splenic stiffness measurement for predicting clinically significant varices in children with portal hypertension: a systematic review and diagnostic test accuracy meta-analysis.BMJ open gastroenterology · 2026Pooled it
- A novel approach to characterize phenotypic variation in GSD IV: Reconceptualizing the clinical continuum.Frontiers in genetics · 2022Pooled it
- Ductular Reaction Underlies Development of Portal Hypertension in Biliary Atresia.Liver international : official journal of the International Association for the Study of the Liver · 2026Article
- Imaging assessment and interventional management of paediatric portal hypertension: an update.Pediatric radiology · 2026Review
- Spleen and liver shear wave elastography for assessment of portal hypertension in children with biliary atresia.Scientific reports · 2026Article
- Association between post-Kasai cholangitis episodes, ursodeoxycholic acid regimen, and portal hypertension risk in biliary atresia: a multicenter cross-sectional study.Pediatric surgery international · 2026Article
- Secondary prophylaxis of variceal hemorrhage in biliary atresia-Analysis of prospective multicenter studies.Journal of pediatric gastroenterology and nutrition · 2026Article
- Shunt Surgery for Pediatric Prehepatic Portal Hypertension: A Single-Center Case Series.Journal of clinical medicine · 2025Article
- Prevalence and Predictors of Pulmonary Hypertension in Children with Portal Hypertension: A Single Center Study.Pediatric gastroenterology, hepatology & nutrition · 2025Article
- Fibrotic liver injury in biliary atresia: long-term implications.World journal of pediatric surgery · 2025Review
- Natural history study of hepatic glycogen storage disease type IV and comparison to Gbe1ys/ys model.JCI insight · 2024Article
- Diseases of bile duct in children.World journal of gastroenterology · 2024Review
- Risk of variceal hemorrhage and pretransplant mortality in children with biliary atresia.Hepatology (Baltimore, Md.) · 2022Article
- The potential of dietary treatment in patients with glycogen storage disease type IV.Journal of inherited metabolic disease · 2021Observational
- Alagille syndrome and non-syndromic paucity of the intrahepatic bile ducts.Translational gastroenterology and hepatology · 2021Review
- Nonfasted Liver Stiffness Correlates with Liver Disease Parameters and Portal Hypertension in Pediatric Cholestatic Liver Disease.Hepatology communications · 2020Article
- Outcomes of Childhood Cholestasis in Alagille Syndrome: Results of a Multicenter Observational Study.Hepatology communications · 2020Article
- Improving the quality of care in pediatric patients with cirrhosis.Clinical liver diseaseReview
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Portal hypertension (PHT) is a major cause of morbidity and mortality in pediatric liver diseases. Thus, research into causes and disease modifiers in PHT in these conditions is vitally important. PHT is rarely directly or indirectly measured in the assessment of children with chronic liver disease. A straightforward, reproducible definition of PHT could be invaluable for consistently identifying patients with PHT and for grouping these patients according to their risk of complications from their disease. We propose the term Clinically Evident Portal Hypertension (CEPH) to denote clinical findings that demonstrate evidence of elevated portal pressure. When CEPH criteria are met, PHT is highly likely to be present, although it is likely that PHT exists for variable periods of time before meeting CEPH criteria. Use of this research definition of CEPH will allow for consistent identification of these patients by clinicians in nearly any clinical setting and serve as a clinical milepost that may dictate future prognosis in pediatric patients with cirrhosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.