Evidence map›Paper›PMID 30907978›Full record

SynthesisTransplant infectious disease : an official journal of the Transplantation Society2019

Native kidney BK virus nephropathy, a systematic review.

Ankur Shah, Vinayak Kumar, Matthew B Palmer, Jennifer Trofe-Clark, Benjamin Laskin, Deirdre Sawinski, Jonathan J Hogan

Open access · greenAbstract readCase ReportsSystematic Review
In one paragraph

Synthesis in Transplant infectious disease : an official journal of the Transplantation Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. BK virus nephropathy in a native kidney.Pediatric nephrology (Berlin, Germany) · 2026
    Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Virus-Associated Nephropathies: A Narrative Review.International journal of molecular sciences · 2022
    Review
  9. Review
  10. Article
  11. Article
  12. Native BK Polyomavirus Nephropathy in an Orthotopic Heart Transplant Patient.Journal of investigative medicine high impact case reports
    Article
  13. BK and JC polyomavirus co-infection resulting in polyomavirus nephropathy and progressive multifocal leukoencephalopathy at the same time, a case report.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Ankur ShahDivision of Nephrology, University of Pennsylvania, Philadelphia, Pennsylvania.ORCID https://orcid.org/0000-0002-0811-6900
Vinayak KumarPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Matthew B PalmerPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Jennifer Trofe-ClarkDivision of Nephrology, University of Pennsylvania, Philadelphia, Pennsylvania.
Benjamin LaskinPerelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
Deirdre SawinskiDivision of Nephrology, University of Pennsylvania, Philadelphia, Pennsylvania.
Jonathan J HoganDivision of Nephrology, University of Pennsylvania, Philadelphia, Pennsylvania.
University of Pennsylvania · USChildren's Hospital of Philadelphia · USHospital of the University of Pennsylvania · US

Funding

Immune dysregulation and kidney disease after hematopoietic cell transplantK23DK101600 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI LASKIN, BENJAMIN LEWIS · 2015 to 2018
$715k
NIDDK NIH HHS K23 DK101600
6 · The paper itself

Abstract

backgroundThere is a growing base of literature describing BK nephropathy (BKVN) in patients outside of the setting of kidney transplant. Previous systematic reviews of the literature have been limited by methodology or by the scope of patients included. STUDY DESIGN AND

methodsSystematic Review (Prospero # CRD42018088524). SETTING & POPULATION: Patients without kidney transplant who had biopsy-proven BKVN. SELECTION CRITERIA FOR STUDIES: Full-text articles that describe native BKVN patient cases. ANALYTICAL APPROACH: Descriptive synthesis.

resultsThe search identified 630 unique articles of which 51 were included in the final review. Sixty-five cases (including two new cases presented in this review) were identified, all but one occurred in the setting of known immunosuppression. LIMITATIONS: The primary limitation was the exclusion of studies that did not fulfill the stringent review criteria. We excluded reports with only a clinical diagnosis of BKVN, such as those with viruria and/or viremia without biopsy.

conclusionsAs of May 2018, there are 65 reported cases of BKVN in native kidneys. This represents the most comprehensive description of biopsy-proven BKVN in native kidneys to date. Evaluation for BK nephropathy should be considered in immunocompromised patients who exhibit unexplained renal failure.

Indexed as

AdultAgedBiopsyBK VirusHumansImmunocompromised HostImmunosuppression TherapyKidneyKidney DiseasesKidney TransplantationMalePolyomavirus InfectionsTumor Virus InfectionsViremiaBK NephropathyBK VirusNRSOTtransplantationTubulointerstitial nephritis

Identifiers

PMID30907978
PMCPMC7197190
OpenAlexW2944264162

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.