Evidence map›Paper›PMID 30907968›Full record

SynthesisThe Journal of clinical endocrinology and metabolism2019

Women's Values and Preferences Regarding Osteoporosis Treatments: A Systematic Review.

Patricia Barrionuevo, Michael R Gionfriddo, Ana Castaneda-Guarderas, Claudia Zeballos-Palacios, Pavithra Bora, Khaled Mohammed, Khalid Benkhadra, Maria Sarigianni, Mohammad Hassan Murad

Abstract readSystematic Review
In one paragraph

Synthesis in The Journal of clinical endocrinology and metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Clinical practice guideline for management of osteoporosis and fracture prevention in Canada: 2023 update.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023
    Guideline
  2. Guideline
  3. Women's Values and Preferences Regarding Osteoporosis Treatments: A Systematic Review.The Journal of clinical endocrinology and metabolism · 2019
    Pooled it
  4. Article
  5. Article
  6. Review
  7. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023
    Article
  8. Article
  9. Article
  10. Article
  11. The clinician's guide to prevention and treatment of osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Article
  12. Review
  13. Health Literacy of Osteoporosis Risks among Caregivers Serving in Disability Care Facilities.International journal of environmental research and public health · 2020
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Patricia BarrionuevoEvidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota.
Michael R GionfriddoKnowledge and Evaluation Research Unit, Mayo Clinic, Rochester, Minnesota.
Ana Castaneda-GuarderasKnowledge and Evaluation Research Unit, Mayo Clinic, Rochester, Minnesota.
Claudia Zeballos-PalaciosKnowledge and Evaluation Research Unit, Mayo Clinic, Rochester, Minnesota.
Pavithra BoraEvidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota.
Khaled MohammedEvidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota.
Khalid BenkhadraEvidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota.
Maria SarigianniEvidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota.
Mohammad Hassan MuradEvidence-Based Practice Center, Mayo Clinic, Rochester, Minnesota.

Funding

Mayo Clinic Center for Translational Science ActivitiesTL1TR000137 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$2.1M
NCATS NIH HHS TL1 TR000137
6 · The paper itself

Abstract

backgroundSeveral treatments are available to reduce the risk of fragility fractures associated with osteoporosis. The choice of treatment requires knowledge of patients' values and preferences. The aim of the present study was to summarize what is known about the values and preferences relevant to the management of osteoporosis in women.

methodsWe conducted a comprehensive search of several databases for studies reported in any language that had included women who had already started or were about to start any pharmacological therapy for osteoporosis. Pairs of reviewers independently selected the studies and extracted the data. The results were synthesized narratively.

resultsWe included 26 studies reporting on 15,348 women (mean age, 66 years). The women considered the effectiveness and adverse events equally, followed by the convenience of taking the drug and its effect on daily routine (less frequent dosing was preferred, the oral route was preferred, and the injectable route was preferred over oral if given less frequently). The treatment cost and duration were less important factors for decision making. Fear of breast cancer and fear of resuming uterine bleeding were common reasons for not choosing estrogen therapy. Calcium and vitamin D were viewed as safe and natural. Across the studies, the preferences were not affected by age, previous drug exposure, or employment status.

conclusionsWomen starting osteoporosis medications value effectiveness and side effects equally and prefer medications given less frequently. Injectable drugs appear acceptable if given less frequently. More research on patient values and preferences is needed to guide decision making in osteoporosis.

Indexed as

Patient PreferenceBone Density Conservation AgentsDecision MakingFemaleHumansOsteoporosis, PostmenopausalOsteoporotic FracturesBone Density Conservation Agents

Identifiers

PMID30907968
PMCPMC7296202

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.