ArticleeLife2019
Biophysical mechanisms in the mammalian respiratory oscillator re-examined with a new data-driven computational model.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Functional synaptic interactions and inhibitory circuitry of the pre-Bötzinger complex in the rhythmic slice.Journal of neurophysiology · 2026Article
- Functional Synaptic Interactions and Inhibitory Circuitry of the PreBötzinger Complex in the Rhythmic Slice.bioRxiv : the preprint server for biology · 2026Article
- Persistent adaptation through dual-timescale regulation of ion channel properties.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Noradrenergic neuromodulation produces a NMDAR-dependent network state of respiratory rhythmogenesis in the preBötzinger Complex.bioRxiv : the preprint server for biology · 2026Article
- Review
- A Computational Model of the Respiratory CPG for the Artificial Control of Breathing.Bioengineering (Basel, Switzerland) · 2025Article
- Persistent Adaptation through Dual-Timescale Regulation of Ion Channel Properties.bioRxiv : the preprint server for biology · 2025Article
- Ionic Mechanisms Underlying Bistability in Spinal Motoneurons: Insights from a Computational Model.bioRxiv : the preprint server for biology · 2025Article
- Ionic mechanisms underlying bistability in spinal motoneurons: insights from a computational model.Frontiers in cellular neuroscience · 2025Article
- Hypoxia evokes a sequence of raphe-pontomedullary network operations for inspiratory drive amplification and gasping.Journal of neurophysiology · 2024Article
- Interdependence of cellular and network properties in respiratory rhythm generation.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Inspiratory and sigh breathing rhythms depend on distinct cellular signalling mechanisms in the preBötzinger complex.The Journal of physiology · 2024Article
- Interdependence of cellular and network properties in respiratory rhythmogenesis.bioRxiv : the preprint server for biology · 2023Article
- Slow negative feedback enhances robustness of square-wave bursting.Journal of computational neuroscience · 2023Article
- Microcircuit Synchronization and Heavy-Tailed Synaptic Weight Distribution Augment preBötzinger Complex Bursting Dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Predictions and experimental tests of a new biophysical model of the mammalian respiratory oscillator.eLife · 2022Article
- Inspiratory rhythm generation is stabilized byJournal of neurophysiology · 2022Article
- Advancing respiratory-cardiovascular physiology with the working heart-brainstem preparation over 25 years.The Journal of physiology · 2022Review
- Dynamics of ramping bursts in a respiratory neuron model.Journal of computational neuroscience · 2022Article
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5 authors.
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Abstract
An autorhythmic population of excitatory neurons in the brainstem pre-Bötzinger complex is a critical component of the mammalian respiratory oscillator. Two intrinsic neuronal biophysical mechanisms-a persistent sodium current ([Formula: see text]) and a calcium-activated non-selective cationic current ([Formula: see text])-were proposed to individually or in combination generate cellular- and circuit-level oscillations, but their roles are debated without resolution. We re-examined these roles in a model of a synaptically connected population of excitatory neurons with [Formula: see text] and [Formula: see text]. This model robustly reproduces experimental data showing that rhythm generation can be independent of [Formula: see text] activation, which determines population activity amplitude. This occurs when [Formula: see text] is primarily activated by neuronal calcium fluxes driven by synaptic mechanisms. Rhythm depends critically on [Formula: see text] in a subpopulation forming the rhythmogenic kernel. The model explains how the rhythm and amplitude of respiratory oscillations involve distinct biophysical mechanisms.
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