Evidence map›Paper›PMID 30907436›Full record

ArticleThe Journal of physiology2019

Enhanced activity of multiple TRIC-B channels: an endoplasmic reticulum/sarcoplasmic reticulum mechanism to boost counterion currents.

Fiona O'Brien, David Eberhardt, Katja Witschas, Sam El-Ajouz, Tsunaki Iida, Miyuki Nishi, Hiroshi Takeshima, Rebecca Sitsapesan, Elisa Venturi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. The ion channels of endomembranes.Physiological reviews · 2024
    Review
  3. CaMKII inhibition due to TRIC-B loss-of-function dysregulates SMAD signaling in osteogenesis imperfecta.Matrix biology : journal of the International Society for Matrix Biology · 2023
    Article
  4. Article
  5. TRIC-A regulates intracellular CaPflugers Archiv : European journal of physiology · 2021
    Review
  6. Article
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Fiona O'BrienDepartment of Pharmacology, University of Oxford, Oxford, UK.ORCID 0000-0002-5647-6791
David EberhardtDepartment of Pharmacology, University of Oxford, Oxford, UK.
Katja WitschasDepartment of Pharmacology, University of Oxford, Oxford, UK.ORCID 0000-0002-0960-683X
Sam El-AjouzDepartment of Pharmacology, University of Oxford, Oxford, UK.
Tsunaki IidaGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Miyuki NishiGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Hiroshi TakeshimaGraduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan.
Rebecca SitsapesanDepartment of Pharmacology, University of Oxford, Oxford, UK.ORCID 0000-0002-3216-2560
Elisa VenturiDepartment of Pharmacology, University of Oxford, Oxford, UK.ORCID 0000-0001-9302-1537
University of Oxford · GBKyoto University · JP

Funding

British Heart Foundation FS/11/31/28790British Heart Foundation FS/11/3128790British Heart Foundation FS/13/5730647British Heart Foundation PG/13/76/30353British Heart Foundation RG/10/14/28576
6 · The paper itself

Abstract

key pointsThere are two subtypes of trimeric intracellular cation (TRIC) channels but their distinct single-channel properties and physiological regulation have not been characterized. We examined the differences in function between native skeletal muscle sarcoplasmic reticulum (SR) K ABSTRACT: The trimeric intracellular cation channels, TRIC-A and TRIC-B, represent two subtypes of sarcoplasmic reticulum (SR) K

Indexed as

AnimalsEndoplasmic ReticulumFemaleIon ChannelsIon ExchangeMaleMiceMice, KnockoutMuscle, SkeletalPotassium Channels, Voltage-GatedSarcoplasmic ReticulumIon ChannelsPotassium Channels, Voltage-GatedTRIC-A protein, mouseTRIC-B protein, mouseCa2+ releaseRyanodine receptorsarcoplasmic reticulumTRIC channels

Identifiers

PMID30907436
PMCPMC6567852
OpenAlexW2939983111

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.