ArticleJournal of the International Association of Providers of AIDS Care
Prolonged QTc in HIV-Infected Patients: A Need for Routine ECG Screening.
Article in Journal of the International Association of Providers of AIDS Care. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Review of electrocardiographic abnormalities among people living with HIV in Sub-Saharan Africa: A systematic review.PloS one · 2023Pooled it
- Baseline ECG and Cardiovascular Outcomes in People With HIV: Insights From REPRIEVE.Journal of the American Heart Association · 2025Observational
- QTc interval prolongation and its associated factors among HIV infected patients on ART in Mettu Town.Scientific reports · 2024Article
- Cardiac arrhythmias in viral infections.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2023Review
- Torsade de pointes associated with long-term antiretroviral drugs in a patient with HIV: a case report.Frontiers in pharmacology · 2023Article
- HIV-Tat Exacerbates the Actions of Atazanavir, Efavirenz, and Ritonavir on Cardiac Ryanodine Receptor (RyR2).International journal of molecular sciences · 2022Article
- Outcomes of implantable cardioverter-defibrillator implantation in HIV-infected patients: A single-center retrospective cohort study.Clinical cardiology · 2022Article
- Prevalence and Correlates of Ischemic ECG Findings among Adults With and Without HIV in Tanzania.Global heart · 2022Article
- Cardiac Abnormalities of People Living with HIV: A Comparative Study Between HAART Experience and Treatment Naïve Groups in Ghana.International journal of general medicine · 2022Article
- Cardiac Corrected QT Interval Changes Among Patients Treated for COVID-19 Infection During the Early Phase of the Pandemic.JAMA network open · 2021Article
- Sudden cardiac death in HIV-infected patients: A contemporary review.Clinical cardiology · 2021Review
- Management of Arrhythmias Associated with COVID-19.Current cardiology reports · 2020Review
- Contribution of Behavioral Health Factors to Non-AIDS-Related Comorbidities: an Updated Review.Current HIV/AIDS reports · 2020Review
- Polypharmacy in HIV: recent insights and future directions.Current opinion in HIV and AIDS · 2020Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundWith HIV-infected patients living longer, there is an increased burden of comorbidities related to aging, HIV itself, and polypharmacy. Cardiac morbidity is of particular importance.
methodsThis 2-group comparison study (156 HIV-positive and 105 HIV-negative patients) investigated the prevalence of abnormalities in and factors associated with an electrocardiogram (ECG) measure, corrected QT interval (QTc), where prolongation can lead to arrhythmia and sudden death. Medications prescribed (antiretroviral therapy, psychiatric medications, methadone, and antibiotics) at the time of ECG were noted. Patient characteristics, medications, QTc, and ECG characteristics were compared between the 2 groups.
resultsProlongation (29% versus 19%) and extreme prolongation (6% versus 1%) in QTc were more frequent in those with HIV. Antiretroviral therapy was associated with lower odds of prolonged QTc (odds ratio [OR] = 0.35; P = .04), while methadone with higher odds (OR = 4.6; P = .01) in HIV-positive patients. With methadone and medication groups adjusted, HIV status was still associated with 17-millisecond longer QTc ( P = .04).
conclusionThis study provides evidence that patients with HIV may have clinically relevant longer QTc interval on ECG. Baseline and routine ECG monitoring may be warranted among patients living with HIV in clinical practice based on cumulative evidence.
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