Evidence map›Paper›PMID 30907072›Full record

ReviewCancer medicine2019

Hope and challenge: Precision medicine in bladder cancer.

Hongwei Su, Haitao Jiang, Tao Tao, Xing Kang, Xu Zhang, Danyue Kang, Shucheng Li, Chengxi Li, Haifeng Wang, Zhao Yang and 2 more

Abstract readReview
In one paragraph

Review in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Metabolomic Signatures of Treatment Response in Bladder Cancer.International journal of molecular sciences · 2023
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hongwei SuDepartment of Urology, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.
Haitao JiangCore Facility for Protein Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Tao TaoCore Facility for Protein Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Xing KangCore Facility for Protein Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Xu ZhangCore Facility for Protein Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Danyue KangMichigan State University, East Lansing, Michigan.
Shucheng LiCore Facility for Protein Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Chengxi LiCore Facility for Protein Research, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
Haifeng WangDepartment of Urology, The Second Affliated Hospital of Kunming Medical University, Kunming, China.
Zhao YangCollege of Life Science and Technology, Beijing University of Chemical Technology, Beijing, China.
Jinku ZhangDepartment of pathology, First Central Hospital of Baoding, Baoding, Hebei, China.
Chong LiDepartment of Urology, Affiliated Traditional Chinese Medicine Hospital, Southwest Medical University, Luzhou, China.ORCID 0000-0003-4654-4479

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bladder cancer (BC) is a complex disease and could be classified into nonmuscle-invasive BC (NMIBC) or muscle-invasive BC (MIBC) subtypes according to the distinct genetic background and clinical prognosis. Until now, the golden standard and confirmed diagnosis of BC is cystoscopy and the major problems of BC are the high rate of recurrence and high costs in the clinic. Recent molecular and genetic studies have provided perspectives on the novel biomarkers and potential therapeutic targets of BC. In this article, we provided an overview of the traditional diagnostic approaches of BC, and introduced some new imaging, endoscopic, and immunological diagnostic technology in the accurate diagnosis of BC. Meanwhile, the minimally invasive precision treatment technique, immunotherapy, chemotherapy, gene therapy, and targeted therapy of BC were also included. Here, we will overview the diagnosis and therapy methods of BC used in clinical practice, focusing on their specificity, efficiency, and safety. On the basis of the discussion of the benefits of precision medicine in BC, we will also discuss the challenges and limitations facing the non-invasive methods of diagnosis and precision therapy of BC. The molecularly targeted and immunotherapeutic approaches, and gene therapy methods to BC treatment improved the prognosis and overall survival of BC patients.

Indexed as

Biomarkers, TumorChemotherapy, AdjuvantCystoscopyGenetic TherapyHumansImmunotherapyMinimally Invasive Surgical ProceduresMolecular Targeted TherapyPrecision MedicinePrognosisUrinary Bladder NeoplasmsBiomarkers, Tumorbladder cancergene therapyimmunotherapyprecision medicine

Identifiers

PMID30907072
PMCPMC6488142

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.