Evidence map›Paper›PMID 30907059›Full record

ArticleAging cell2019

1,25-Dihydroxyvitamin D exerts an antiaging role by activation of Nrf2-antioxidant signaling and inactivation of p16/p53-senescence signaling.

Lulu Chen, Renlei Yang, Wanxin Qiao, Wei Zhang, Jie Chen, Li Mao, David Goltzman, Dengshun Miao

RetractedOpen access · goldAbstract readRetracted Publication
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 105 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 2 pooled it
18.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

105 citing papers in PubMed, 2 syntheses or guidelines pooled it, 205 citations in OpenAlex.

  1. Pooled it
  2. Efficacy of vitamin DAgeing research reviews · 2023
    Pooled it
  3. Trial
  4. Article
  5. Nrf2 signaling pathway: focus on oxidative stress in osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Review
  6. Dietary cholecalciferol and 25-hydroxyvitamin DAnimal nutrition (Zhongguo xu mu shou yi xue hui) · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Calcitriol Inhibits NaAsOBiological trace element research · 2024
    Article
  17. Calcitriol Inhibits NaAsOBiological trace element research · 2024
    Article
  18. Review
  19. Review
  20. Article

45 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Lulu ChenState Key Laboratory of Reproductive Medicine, The Research Center for Bone and Stem Cells, Department of Anatomy, Histology and Embryology, Nanjing Medical University, Nanjing, China.
Renlei YangState Key Laboratory of Reproductive Medicine, The Research Center for Bone and Stem Cells, Department of Anatomy, Histology and Embryology, Nanjing Medical University, Nanjing, China.
Wanxin QiaoState Key Laboratory of Reproductive Medicine, The Research Center for Bone and Stem Cells, Department of Anatomy, Histology and Embryology, Nanjing Medical University, Nanjing, China.
Wei ZhangState Key Laboratory of Reproductive Medicine, The Research Center for Bone and Stem Cells, Department of Anatomy, Histology and Embryology, Nanjing Medical University, Nanjing, China.
Jie ChenState Key Laboratory of Reproductive Medicine, The Research Center for Bone and Stem Cells, Department of Anatomy, Histology and Embryology, Nanjing Medical University, Nanjing, China.
Li MaoDepartment of Endocrinology, Huai'an First People's Hospital, Nanjing Medical University, Huai'an, China.
David GoltzmanCalcium Research Laboratory, McGill University Health Centre and Department of Medicine, McGill University, Montreal, Quebec, Canada.
Dengshun MiaoState Key Laboratory of Reproductive Medicine, The Research Center for Bone and Stem Cells, Department of Anatomy, Histology and Embryology, Nanjing Medical University, Nanjing, China.
Nanjing Medical University · CNMcGill University Health Centre · CA

Funding

CIHRNational Basic Research Program of China 2014CB942900National Natural Science Foundation of China 81230009National Natural Science Foundation of China 81400789National Natural Science Foundation of China 81471501National Natural Science Foundation of China 81500682National Natural Science Foundation of China 81730066
6 · The paper itself

Abstract

We tested the hypothesis that 1,25-dihydroxyvitamin D

Indexed as

AcetylcysteineAnimalsAntioxidantsCalciumCell ProliferationCellular SenescenceCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21DNA DamageFemaleLongevityMaleMiceMice, Inbred BALB CMice, Inbred C57BLMice, Transgenic1,25-dihydroxyvitamin DAcetylcysteineAntioxidantsCalciumCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21Nfe2l2 protein, mouseNF-E2-Related Factor 2PhosphorusReceptors, CalcitriolTrp53 protein, mouseTumor Suppressor Protein p53Vitamin Dagingcell senescenceNrf2p16 and p53vitamin D

Identifiers

PMID30907059
PMCPMC6516172
OpenAlexW2944993420

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.