Evidence map›Paper›PMID 30906878›Full record

ArticleJournal of scleroderma and related disorders2019

An Interim Report of the Scleroderma Clinical Trials Consortium Working Groups.

Murray Baron, Bashar Kahaleh, Elana J Bernstein, Lorinda Chung, Philip J Clements, Christopher Denton, Robyn T Domsic, Nava Ferdowsi, Ivan Foeldvari, Tracy Frech and 12 more

Open access · greenAbstract read
In one paragraph

Article in Journal of scleroderma and related disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 16 institutions in 5 countries.

Murray BaronDivision of Rheumatology, Jewish General Hospital, Montreal, Canada.
Bashar KahalehFaculty of Rheumatology, University of Toledo Medical Center, Toledo, OH, USA.
Elana J BernsteinColumbia University College of Physicians and Surgeons, New York, New York.
Lorinda ChungDepartment of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, USA.
Philip J ClementsRonald Reagan UCLA Medical Center, Los Angeles, CA, USA; University College London, London, United Kingdom.
Christopher DentonInsitute of Immunity and Transplantation, University College London, London, United Kingdom.
Robyn T DomsicArthritis and Autoimmunity Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
Nava FerdowsiDivision of Rheumatology, St. Vincent's Hospital, Melbourne, Australia.
Ivan FoeldvariHamburg Centre for Pediatric Rheumatology, Hamburg, Germany.
Tracy FrechDepartment of Rheumatology, University of Utah, UT, USA.
Jessica K GordonDepartment of Rheumatology, Hospital for Special Surgery, New York, NY, USA.
Marie HudsonDivision of Rheumatology, Jewish General Hospital, Montreal, Canada.
Sindhu R JohnsonDepartment of Rheumatology, Toronto Western Hospital, Toronto, Canada.
Dinesh KhannaDivision of Rheumatology, University of Michigan, MI, USA.
Zsuzsannah McMahanRheumatology Department, Johns Hopkins Hospital, M.D., USA.
Peter A MerkelDepartment of Medicine, University of Pennsylvania, PA, USA.
Sonali NarainDepartment of Rheumatology, Hosfra Northwell School of Medicine.
Mandana NikpourDivision of Rheumatology, St. Vincent's Hospital, Melbourne, Australia.
John D PaulingDepartment of Rheumatology, Royal National Hospital for Rheumatic Diseases University of Bath.
Laura RossDivision of Rheumatology, St. Vincent's Hospital, Melbourne, Australia.
Antonia Maria Valenzuela VergaraDepartment of Immunology and Rheumatology, Stanford University School of Medicine, Palo Alto, CA, USA.
Alessandra VaccaRheumatology Unit, University Hospital of Cagliari.
St Vincent's Hospital · AUJewish General Hospital · CAStanford University · USUniversity College London · GBColumbia University · USDonald & Barbara Zucker School of Medicine at Hofstra/Northwell · USHospital for Special Surgery · USJohns Hopkins Hospital · USToronto Western Hospital · CAUniversity of Bath · GBUniversity of Cagliari · ITUniversity of Michigan–Ann Arbor · USUniversity of Pennsylvania · USUniversity of Pittsburgh Medical Center · USUniversity of Toledo Medical Center · USUniversity of Utah · US

Funding

Utah Center for Clinical and Translational ScienceUL1TR002538 · NCATS · UNIVERSITY OF UTAH · PI HESS, RACHEL, MAJERSIK, JENNIFER JUHL · 2018 to 2022
$26.0M
Scleroderma and Gastrointestinal Disease: Insights into Clinical Phenotypes and Disease PathogenesisK23AR071473 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI MCMAHAN, ZSUZSANNA HORTOBAGYI · 2018 to 2022
$808k
NCATS NIH HHS UL1 TR002538NIAMS NIH HHS K23 AR071473
6 · The paper itself

Abstract

The Scleroderma Clinical Trials Consortium (SCTC) represents many of the clinical researchers in the world who are interested in improving the efficiency of clinical trials in Systemic Sclerosis (SSc). The SCTC has established 11 working groups (WGs) to develop and validate better ways of measuring and recording multiple aspects of this heterogeneous disease. These include groups working on arthritis, disease damage, disease activity, cardiac disease, juvenile SSc, the gastrointestinal tract, vascular component, calcinosis, scleroderma renal crisis, interstitial lung disease, and skin measurement. Members of the SCTC may join any one or more of these groups. Some of the WGs have only recently started their work, some are nearing completion of their mandated tasks and others are in the midst of their projects. All these projects, which are described in this paper, will help to improve clinical trials and observational studies by improving or developing better, more sensitive ways of measuring various aspects of the disease. As Lord Kelvin stated, "To measure is to know. If you cannot measure it you cannot improve it." The SCTC is dedicated to improving the lives of patients with SSc and it is our hope that the contributions of the WGs will be one important step in this process.

Identifiers

PMID30906878
PMCPMC6428445
OpenAlexW2884986837

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.