Evidence map›Paper›PMID 30906859›Full record

ArticleScience advances2019

Hypoxia and matrix viscoelasticity sequentially regulate endothelial progenitor cluster-based vasculogenesis.

Michael R Blatchley, Franklyn Hall, Songnan Wang, Hawley C Pruitt, Sharon Gerecht

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 71 citations in OpenAlex.

  1. Review
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  10. Beyond classical collagen: basement membrane collagen IV in age-associated lung diseases.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  11. Review
  12. Review
  13. Acute Three-Dimensional Hypoxia Regulates Angiogenesis.Advanced healthcare materials · 2025
    Article
  14. Review
  15. Article
  16. Endothelial progenitor cells in pregnancy-related diseases.Clinical science (London, England : 1979) · 2023
    Review
  17. The extracellular matrix mechanics in the vasculature.Nature cardiovascular research · 2023
    Review
  18. Cell-extracellular matrix mechanotransduction in 3D.Nature reviews. Molecular cell biology · 2023
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Michael R BlatchleyDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0002-2069-4623
Franklyn HallDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Songnan WangDepartment of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology and Johns Hopkins Physical Sciences-Oncology Center, Johns Hopkins University, Baltimore, MD 21218, USA.
Hawley C PruittDepartment of Chemical and Biomolecular Engineering, Institute for NanoBioTechnology and Johns Hopkins Physical Sciences-Oncology Center, Johns Hopkins University, Baltimore, MD 21218, USA.
Sharon GerechtDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
Johns Hopkins University · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI WILLIAM George NELSON · 1985 to 2026
$208.6M
BIOMEDICAL ENGINEERING TRAINING PROGRAMT32GM007057 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI KANOLD, PATRICK O, KARCHIN, RACHEL · 1985 to 2023
$10.4M
The Role of Physical Cues in Collective Cell InvasionU54CA210173 · NCI · JOHNS HOPKINS UNIVERSITY · PI PIENTA, KENNETH J., WIRTZ, DENIS · 2016 to 2020
$9.9M
T32: Predoctoral and Postdoctoral Training Program in Nanotechnology for Cancer ResearchT32CA153952 · NCI · JOHNS HOPKINS UNIVERSITY · PI Denis Wirtz · 2015 to 2026
$3.5M
T-32 NIH Postdoctoral Training Program in Nanotechnology for Cancer Medicine NTCMT32CA130840 · NCI · JOHNS HOPKINS UNIVERSITY · PI WIRTZ, DENIS · 2008 to 2012
$1.2M
Elucidating a mechanism for hypoxic cluster-based vasculogenesisF31HL137339 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI BLATCHLEY, MICHAEL · 2017 to 2019
$93k
NCI NIH HHS P30 CA006973NCI NIH HHS T32 CA130840NCI NIH HHS T32 CA153952NCI NIH HHS U54 CA210173NHLBI NIH HHS F31 HL137339NIGMS NIH HHS T32 GM007057
6 · The paper itself

Abstract

Vascular morphogenesis is the formation of endothelial lumenized networks. Cluster-based vasculogenesis of endothelial progenitor cells (EPCs) has been observed in animal models, but the underlying mechanism is unknown. Here, using O

Indexed as

AnimalsAntigens, CDBlood VesselsCadherin 5CadherinsCarcinogenesisCD18 AntigensCell CommunicationCell HypoxiaEndothelial Progenitor CellsExtracellular MatrixHumansHydrogelsIntercellular Adhesion Molecule-1Matrix Metalloproteinase 1MiceAntigens, CDCadherin 5CadherinsCD18 AntigensHydrogelsIntercellular Adhesion Molecule-1Matrix Metalloproteinase 1Reactive Oxygen Species

Identifiers

PMID30906859
PMCPMC6426463
OpenAlexW2922555728

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.