ArticleScience advances2019
A hidden state in the turnover of a functioning membrane protein complex.
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed.
- Dynamic velocity response of E. coli powered by proteorhodopsin.Biophysical reports · 2026Article
- An optically driven microstructure for torque measurement in rotary molecular motors.Microsystems & nanoengineering · 2026Article
- Structure and Dynamics of the Bacterial Flagellar Motor Complex.Biomolecules · 2024Review
- Flagellar motors of swimming bacteria contain an incomplete set of stator units to ensure robust motility.Science advances · 2023Article
- FliL Differentially Interacts with Two Stator Systems To Regulate Flagellar Motor Output in Pseudomonas aeruginosa.Applied and environmental microbiology · 2022Article
- A multi-state dynamic process confers mechano-adaptation to a biological nanomachine.Nature communications · 2022Article
- Article
- Dynamics of the Two Stator Systems in the Flagellar Motor of Pseudomonas aeruginosa Studied by a Bead Assay.Applied and environmental microbiology · 2021Article
- Stator Dynamics Depending on Sodium Concentration in Sodium-Driven Bacterial Flagellar Motors.Frontiers in microbiology · 2021Article
- Load-dependent adaptation near zero load in the bacterial flagellar motor.Journal of the Royal Society, Interface · 2019Article
- Flagella-Driven Motility of Bacteria.Biomolecules · 2019Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most membrane proteins exist in complexes that carry out critical cellular functions and exhibit rich dynamics. The bacterial flagellar motor, a large membrane-spanning ion-driven rotary motor that propels the bacteria to swim, provides a canonical example. Rotation of the motor is driven by multiple torque-generating units (stators). Turnover of the stators has been shown previously, demonstrating the exchange of stator units between the motor and a membrane pool. But the details of the turnover kinetics remain unclear. Here, we directly measured the kinetics of stator turnover in individual motors via analysis of a large dataset of long-term high-resolution recordings of motor speed at high load. We found that the dwell time distribution of the stator units exhibits a multi-exponential shape, suggesting the existence of a hidden state in the turnover of the stators.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.