Evidence map›Paper›PMID 30906853›Full record

ArticleAdvanced biosystems2018

Stereolithographic 4D Bioprinting of Multiresponsive Architectures for Neural Engineering.

Shida Miao, Haitao Cui, Margaret Nowicki, Lang Xia, Xuan Zhou, Se-Jun Lee, Wei Zhu, Kausik Sarkar, Zhiyong Zhang, Lijie Grace Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced biosystems, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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  6. The interaction between oxidative stress and Schwann cells.Experimental biology and medicine (Maywood, N.J.) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shida MiaoDepartment of Aerospace and Mechanical Engineering, The George Washington University, 800 22nd St NW, Washington, DC 20052, USA, lgzhang@gwu.edu.
Haitao CuiDepartment of Aerospace and Mechanical Engineering, The George Washington University, 800 22nd St NW, Washington, DC 20052, USA, lgzhang@gwu.edu.
Margaret NowickiDepartment of Aerospace and Mechanical Engineering, The George Washington University, 800 22nd St NW, Washington, DC 20052, USA, lgzhang@gwu.edu.
Lang XiaDepartment of Aerospace and Mechanical Engineering, The George Washington University, 800 22nd St NW, Washington, DC 20052, USA, lgzhang@gwu.edu.
Xuan ZhouDepartment of Aerospace and Mechanical Engineering, The George Washington University, 800 22nd St NW, Washington, DC 20052, USA, lgzhang@gwu.edu.
Se-Jun LeeDepartment of Aerospace and Mechanical Engineering, The George Washington University, 800 22nd St NW, Washington, DC 20052, USA, lgzhang@gwu.edu.
Wei ZhuDepartment of Aerospace and Mechanical Engineering, The George Washington University, 800 22nd St NW, Washington, DC 20052, USA, lgzhang@gwu.edu.
Kausik SarkarDepartment of Aerospace and Mechanical Engineering, The George Washington University, 800 22nd St NW, Washington, DC 20052, USA, lgzhang@gwu.edu.
Zhiyong ZhangTranslational Research Centre of Regenerative Medicine and 3D Printing Technologies of Guangzhou Medical University, The Third Affiliated Hospital of Guangzhou Medical University, No. 63 Duobao Road, Liwan District, Guangzhou City, Guangdong, Province 510150, P. R. China.
Lijie Grace ZhangDepartment of Aerospace and Mechanical Engineering, The George Washington University, 800 22nd St NW, Washington, DC 20052, USA, lgzhang@gwu.edu.

Funding

A Novel 3D Bioprinted Smart Vascularized Nano TissueDP2EB020549 · NIBIB · GEORGE WASHINGTON UNIVERSITY · PI ZHANG, LIJIE GRACE · 2014 to 2014
$2.3M
NIBIB NIH HHS DP2 EB020549
6 · The paper itself

Abstract

4D printing represents one of the most advanced fabrication techniques for prospective applications in tissue engineering, biomedical devices, and soft robotics, among others. In this study, a novel multiresponsive architecture is developed through stereolithography-based 4D printing, where a universal concept of stress-induced shape transformation is applied to achieve the 4D reprogramming. The light-induced graded internal stress followed by a subsequent solvent-induced relaxation, driving an autonomous and reversible change of the programmed configuration after printing, is employed and investigated in depth and details. Moreover, the fabricated construct possesses shape memory property, offering a characteristic of multiple shape change. Using this novel multiple responsive 4D technique, a proof-of-concept smart nerve guidance conduit is demonstrated on a graphene hybrid 4D construct providing outstanding multifunctional characteristics for nerve regeneration including physical guidance, chemical cues, dynamic self-entubulation, and seamless integration. By employing this fabrication technique, creating multiresponsive smart architectures, as well as demonstrating application potential, this work paves the way for truly initiation of 4D printing in various high-value research fields.

Indexed as

4D bioprintingmultiresponsiveshape memorysmart biomaterialstissue engineering

Identifiers

PMID30906853
PMCPMC6430203

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.